Institute of Pathology, Medical Center Coburg, Ketschendorferstr. 33, 96450 Coburg, Germany.
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S2-6. doi: 10.1016/j.joca.2010.07.013.
Animal model systems represent an important adjunct and surrogate for studies of osteoarthritis (OA) in humans. They provide a means to study OA pathophysiology as well as aid in the development of therapeutic agents and biological markers for diagnosing and prognosing the disease. Thus, it is of great importance for the OA scientific community, both in academic as well as industrial research, to standardize scoring systems for evaluating the OA disease process and to make results between different studies comparable. The task of the histopathology initiative of OARSI was to achieve a consensus of scoring systems for the most important species used in OA animal model research (dog, guinea pig, horse, mouse, rabbit, rat, and sheep/goat), which are presented in the various chapters in this special volume of Osteoarthritis & Cartilage together with extra chapters on basic methodology (histochemistry, statistics, morphometry), the specific terminology and a general discussion of animal models in OA research. Standardized definitions are suggested for basic but essential terms such as "grading" and "staging" in order to promote their consistent use and thereby promote improved understanding and data interpretation across all model systems. Thus, this introductory chapter presents an overview of the guiding principles for assessment of important OA animal model systems. Use of such systems, independently or in conjunction with other systems in parallel, should facilitate comparability of results across animal model studies.
动物模型系统是研究人类骨关节炎（OA）的重要辅助和替代方法。它们提供了一种研究 OA 病理生理学的手段，并有助于开发治疗剂和生物标志物，用于诊断和预测疾病。因此，对于 OA 科学界，无论是在学术还是工业研究中，标准化评分系统以评估 OA 疾病过程并使不同研究之间的结果具有可比性都非常重要。OARSI 组织病理学倡议的任务是就用于 OA 动物模型研究的最重要物种（狗、豚鼠、马、鼠、兔、鼠和绵羊/山羊）达成评分系统的共识，这些共识在本特刊的各个章节中呈现，此外还有关于基本方法学（组织化学、统计学、形态计量学）、特定术语以及 OA 研究中动物模型的一般讨论的章节。为了促进其一致使用，从而促进所有模型系统的理解和数据解释的提高，建议对“分级”和“分期”等基本但重要的术语进行标准化定义。因此，本章介绍了评估重要 OA 动物模型系统的指导原则概述。单独或与其他系统一起平行使用这些系统，应有助于跨动物模型研究比较结果的可比性。
