Institute of Computational Medicine and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Wiley Interdiscip Rev Syst Biol Med. 2011 Jul-Aug;3(4):392-413. doi: 10.1002/wsbm.122. Epub 2010 Sep 23.
Cardiac electrophysiology is a discipline with a rich 50-year history of experimental research coupled with integrative modeling which has enabled us to achieve a quantitative understanding of the relationships between molecular function and the integrated behavior of the cardiac myocyte in health and disease. In this paper, we review the development of integrative computational models of the cardiac myocyte. We begin with a historical overview of key cardiac cell models that helped shape the field. We then narrow our focus to models of the cardiac ventricular myocyte and describe these models in the context of their subcellular functional systems including dynamic models of voltage-gated ion channels, mitochondrial energy production, ATP-dependent and electrogenic membrane transporters, intracellular Ca dynamics, mechanical contraction, and regulatory signal transduction pathways. We describe key advances and limitations of the models as well as point to new directions for future modeling research. WIREs Syst Biol Med 2011 3 392-413 DOI: 10.1002/wsbm.122
心脏电生理学是一门拥有 50 年历史的学科，其研究涵盖了丰富的实验和综合建模内容，使我们能够定量理解分子功能与心脏细胞在健康和疾病状态下的整体行为之间的关系。在本文中，我们回顾了心脏细胞综合计算模型的发展历程。首先，我们简要回顾了对该领域产生重要影响的关键心脏细胞模型。然后，我们将重点缩小到心室肌细胞模型，并根据其亚细胞功能系统（包括电压门控离子通道、线粒体能量产生、ATP 依赖性和电致膜转运体、细胞内 Ca 动力学、机械收缩和调节信号转导途径）来描述这些模型。我们描述了模型的关键进展和局限性，并指出了未来建模研究的新方向。
