DNA纳米结构：从组装到应用的转变
DNA nanostructures: a shift from assembly to applications.
作者信息
Lanier Laura A, Bermudez Harry
机构信息
Department of Polymer Science and Engineering, University of Massachusetts, Amherst MA 01003.
出版信息
Curr Opin Chem Eng. 2015 Feb 1;7:93-100. doi: 10.1016/j.coche.2015.01.001.
Abstract
The specificity of DNA hybridization allows for the modular design of 2D and 3D shapes with wide-ranging applications including sensors, actuators, and even logic devices. The inherent biocompatibility of DNA and the ability to produce monodisperse structures of controlled shape and size make DNA nanostructures of interest as potential drug and gene delivery vehicles. In this review, we discuss several new approaches for the assembly of DNA nanostructures, advances in the modeling of these structures, and we highlight recent studies on the use of DNA nanotechnology for therapeutic applications such as drug delivery in tumor models.
摘要
DNA杂交的特异性使得二维和三维形状的模块化设计成为可能，其应用广泛，包括传感器、致动器，甚至逻辑器件。DNA固有的生物相容性以及生成形状和大小可控的单分散结构的能力，使得DNA纳米结构成为潜在的药物和基因递送载体而备受关注。在本综述中，我们讨论了几种DNA纳米结构组装的新方法、这些结构建模的进展，并着重介绍了近期关于利用DNA纳米技术用于治疗应用（如肿瘤模型中的药物递送）的研究。
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