Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
ACS Nano. 2010 Sep 28;4(9):4967-70. doi: 10.1021/nn102324e.
The ability to apply nanomaterials as targeted delivery agents for drugs and other therapeutics holds promise for a wide variety of diseases, including many types of cancer. A nanodelivery vehicle must demonstrate in vivo efficacy, diminished or no toxicity, stability, improved pharmacokinetics, and controlled-release kinetics. In this issue, Lee et al. construct polymer nanobins that fulfill these requirements and demonstrate effective delivery of doxorubicin in vivo to breast cancer cells. This Perspective explores the outlook for these nanobins as well as other technologies in this field and the challenges that lie ahead.
将纳米材料作为药物和其他治疗药物的靶向递送剂的应用能力为各种疾病（包括许多类型的癌症）带来了希望。纳米递药载体必须表现出体内疗效、降低或无毒性、稳定性、改善药代动力学和控制释放动力学。在本期中，Lee 等人构建了满足这些要求的聚合物纳米盒，并证明了阿霉素在体内向乳腺癌细胞的有效递送。本观点探讨了这些纳米盒以及该领域其他技术的前景，以及未来面临的挑战。
