基质金属蛋白酶-9（MMP-9）在喉鳞状细胞癌中的表达及血管密度
Expression of matrix metalloproteinase-9 (MMP-9) and blood vessel density in laryngeal squamous cell carcinomas.
作者信息
Wittekindt Claus, Jovanovic Nebojsa, Guntinas-Lichius Orlando
机构信息
Department of Otorhinolaryngology, Justus Liebig University, Giessen, Germany.
出版信息
Acta Otolaryngol. 2011 Jan;131(1):101-6. doi: 10.3109/00016489.2010.506886. Epub 2010 Sep 27.
CONCLUSION
In this study we found that inflammatory cells may be a source of MMP-9 in laryngeal cancer. MMP-9 was correlated with blood vessel density. MMP-9 may be a potential target to disrupt tumor neovascularization.
OBJECTIVE
To study the expression of MMP-9 in laryngeal cancer and determine a possible relation with blood vessel density.
METHODS
Immunohistochemistry was used for MMP analysis and for blood vessel detection in 83 laryngeal cancer samples. The density of blood vessels was analyzed with a stereological tool.
RESULTS
MMP-9 was detected in inflammatory cells. Positivity for MMP-9 correlated significantly with the grade of differentiation (p = 0.025). Expression of MMP-9 was not correlated with T stage, nodal metastasis, or tumor recurrence. The mean blood vessel density was 51.4 vessels/mm². Specimens were more likely to exhibit higher density of blood vessels when MMP-9 expression was also present (p = 0.014).
结论
在本研究中，我们发现炎症细胞可能是喉癌中基质金属蛋白酶-9（MMP-9）的来源。MMP-9与血管密度相关。MMP-9可能是破坏肿瘤新生血管形成的一个潜在靶点。
目的
研究MMP-9在喉癌中的表达，并确定其与血管密度之间可能存在的关系。
方法
采用免疫组织化学方法对83例喉癌样本进行MMP分析和血管检测。使用体视学工具分析血管密度。
结果
在炎症细胞中检测到MMP-9。MMP-9阳性与分化程度显著相关（p = 0.025）。MMP-9的表达与T分期、淋巴结转移或肿瘤复发无关。平均血管密度为51.4条血管/mm²。当MMP-9表达也存在时，标本更有可能表现出更高的血管密度（p = 0.014）。
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