Wittekindt Claus, Jovanovic Nebojsa, Guntinas-Lichius Orlando
Department of Otorhinolaryngology, Justus Liebig University, Giessen, Germany.
Acta Otolaryngol. 2011 Jan;131(1):101-6. doi: 10.3109/00016489.2010.506886. Epub 2010 Sep 27.
In this study we found that inflammatory cells may be a source of MMP-9 in laryngeal cancer. MMP-9 was correlated with blood vessel density. MMP-9 may be a potential target to disrupt tumor neovascularization.
To study the expression of MMP-9 in laryngeal cancer and determine a possible relation with blood vessel density.
Immunohistochemistry was used for MMP analysis and for blood vessel detection in 83 laryngeal cancer samples. The density of blood vessels was analyzed with a stereological tool.
MMP-9 was detected in inflammatory cells. Positivity for MMP-9 correlated significantly with the grade of differentiation (p = 0.025). Expression of MMP-9 was not correlated with T stage, nodal metastasis, or tumor recurrence. The mean blood vessel density was 51.4 vessels/mm². Specimens were more likely to exhibit higher density of blood vessels when MMP-9 expression was also present (p = 0.014).
在本研究中，我们发现炎症细胞可能是喉癌中基质金属蛋白酶-9（MMP-9）的来源。MMP-9与血管密度相关。MMP-9可能是破坏肿瘤新生血管形成的一个潜在靶点。
研究MMP-9在喉癌中的表达，并确定其与血管密度之间可能存在的关系。
采用免疫组织化学方法对83例喉癌样本进行MMP分析和血管检测。使用体视学工具分析血管密度。
在炎症细胞中检测到MMP-9。MMP-9阳性与分化程度显著相关（p = 0.025）。MMP-9的表达与T分期、淋巴结转移或肿瘤复发无关。平均血管密度为51.4条血管/mm²。当MMP-9表达也存在时，标本更有可能表现出更高的血管密度（p = 0.014）。
