Department of Chinese Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
Chin Med. 2010 Sep 27;5:34. doi: 10.1186/1749-8546-5-34.
The dried flowers and buds of Sophora japonica are used as a medicinal herb in China, Japan and Korea to treat bleeding hemorrhoids and hematemesis. This article presents an overview of the effects of Sophora japonica on cerebral infarction based on literature searched from Medline, PubMed, Cochrane Library and the China National Knowledge Infrastructure (CNKI). Sophora japonica contains both anti-hemorrhagic and anti-hemostatic substances. Sophora japonica reduces cerebral infarction partly as a result of its anti-oxidative and anti-inflammatory activities. Previous studies found that Sophora japonica reduced the size of cerebral infarction and neurological deficits and reduced microglial activation, interleukin-1β release and number of apoptotic cells in ischemia-reperfusion injured Sprague-Dawley rats. Further study is required to determine the relationship between Sophora japonica-mediated reduction in cerebral infarction size and the effects of Sophora japonica on platelet aggregation and cardiovascular function.
槐米在中、日、韩被用作草药,以治疗出血性痔疮和呕血。本文通过对 Medline、PubMed、Cochrane Library 和中国知网(CNKI)检索的文献进行综述,概述了槐米对脑梗死的影响。槐米含有止血和抗凝血物质。槐米通过抗氧化和抗炎作用部分减轻脑梗死。先前的研究发现,槐米可缩小脑梗死体积和减轻神经功能缺损,并减少缺血再灌注损伤的 Sprague-Dawley 大鼠小胶质细胞激活、白细胞介素-1β释放和细胞凋亡数量。需要进一步研究以确定槐米缩小脑梗死体积与槐米对血小板聚集和心血管功能的影响之间的关系。