Section of Pulmonary and Critical Care Medicine, University of Chicago Pritzker School of Medicine, Chicago IL 60637, USA.
Respir Care. 2010 Oct;55(10):1347-62; discussion 1363-5.
Obesity hyoventilation syndrome (OHS) is defined as the triad of obesity, daytime hypoventilation, and sleep-disordered breathing in the absence of an alternative neuromuscular, mechanical or metabolic explanation for hypoventilation. During the last 3 decades the prevalence of extreme obesity has markedly increased in the United States and other countries. With such a global epidemic of obesity, the prevalence of OHS is bound to increase. Patients with OHS have a lower quality of life, with increased healthcare expenses, and are at higher risk of developing pulmonary hypertension and early mortality, compared to eucapnic patients with sleep-disordered breathing. OHS often remains undiagnosed until late in the course of the disease. Early recognition is important, as these patients have significant morbidity and mortality. Effective treatment can lead to significant improvement in patient outcomes, underscoring the importance of early diagnosis. This review will include disease definition and epidemiology, clinical characteristics of the syndrome, pathophysiology, and morbidity and mortality associated with it. Lastly, treatment modalities will be discussed in detail.
肥胖通气不足综合征（OHS）定义为肥胖、白天通气不足和睡眠呼吸障碍三联征，无通气不足的替代神经肌肉、机械或代谢原因。在过去的 30 年中，美国和其他国家的极端肥胖患病率显著增加。随着肥胖的全球性流行，OHS 的患病率势必会增加。与无高碳酸血症睡眠呼吸障碍的患者相比，OHS 患者的生活质量较低，医疗费用增加，患肺动脉高压和早期死亡率的风险更高。OHS 通常在疾病晚期才被诊断出来。早期识别很重要，因为这些患者有显著的发病率和死亡率。有效的治疗可以显著改善患者的预后，凸显出早期诊断的重要性。本文将综述该病的定义和流行病学、综合征的临床特征、病理生理学以及相关发病率和死亡率，最后详细讨论治疗方法。
