含 ITAM 的免疫受体抑制信号转导的难题：潜在的分子机制。
The conundrum of inhibitory signaling by ITAM-containing immunoreceptors: potential molecular mechanisms.
机构信息
Integrated Department of Immunology, University of Colorado School of Medicine, Denver CO 80206, USA.
出版信息
FEBS Lett. 2010 Dec 15;584(24):4878-82. doi: 10.1016/j.febslet.2010.09.029. Epub 2010 Sep 28.
Abstract
Immunoreceptor signals must be appropriately transduced and regulated to achieve effective immunity while controlling inflammation and autoimmunity. It is generally held that these processes are mediated by the interplay of distinct activating and inhibitory receptors via conserved activating (ITAM) and inhibitory (ITIM) signaling motifs. However, recent evidence indicates that under certain conditions incomplete phosphorylation of ITAM tyrosines leads to inhibitory signaling. This new regulatory function of ITAMs has been termed ITAMi (inhibitory ITAM). Here we discuss the potential molecular mechanisms of inhibitory signaling by ITAM-containing receptors.
摘要
免疫受体信号必须进行适当的转导和调节，以在控制炎症和自身免疫的同时实现有效的免疫。人们普遍认为，这些过程是通过独特的激活和抑制受体通过保守的激活（ITAM）和抑制（ITIM）信号基序的相互作用来介导的。然而，最近的证据表明，在某些条件下，ITAM 酪氨酸的不完全磷酸化会导致抑制性信号。这种 ITAM 的新调节功能被称为 ITAMi（抑制性 ITAM）。在这里，我们讨论了含 ITAM 受体的抑制性信号传递的潜在分子机制。
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