牛和猪耐甲氧西林金黄色葡萄球菌 ST398 分离株中新的 Apramycin 抗性基因 apmA。
Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates.
机构信息
Institute of Farm Animal Genetics, Friedrich-Loeffler-Institut, Neustadt-Mariensee, Germany.
出版信息
Antimicrob Agents Chemother. 2011 Jan;55(1):373-5. doi: 10.1128/AAC.01124-10. Epub 2010 Sep 27.
Abstract
A novel apramycin resistance gene, apmA, was detected on the ca.-40-kb resistance plasmid pAFS11 from bovine methicillin-resistant Staphylococcus aureus (MRSA) of sequence type 398 (ST398). The apmA gene coded for a protein of 274 amino acids that was related only distantly to acetyltransferases involved in chloramphenicol or streptogramin A resistance. NsiI deletion of apmA resulted in a 16- to 32-fold decrease in the apramycin MICs. An apmA-specific PCR identified this gene in one additional bovine and four porcine MRSA ST398 isolates.
摘要
从牛耐甲氧西林金黄色葡萄球菌（MRSA）序列型 398（ST398）中分离到的 ca.-40-kb 耐药质粒 pAFS11 上检测到一种新型安普霉素耐药基因 apmA。apmA 基因编码一个 274 个氨基酸的蛋白，与参与氯霉素或链阳性菌素 A 耐药的乙酰转移酶仅有远缘关系。NsiI 缺失 apmA 导致安普霉素 MIC 值降低 16-32 倍。apmA 特异性 PCR 鉴定了另外 1 株牛源和 4 株猪源 ST398 耐甲氧西林金黄色葡萄球菌分离株中的该基因。
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