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本文引用的文献

1
Ultrasound-enhanced delivery of targeted echogenic liposomes in a novel ex vivo mouse aorta model.超声增强靶向声敏脂质体在新型离体小鼠主动脉模型中的传递。
J Control Release. 2010 Jun 15;144(3):288-95. doi: 10.1016/j.jconrel.2010.02.030. Epub 2010 Mar 2.
2
Simulation of intracranial acoustic fields in clinical trials of sonothrombolysis.超声溶栓临床试验中颅内声场的模拟
Ultrasound Med Biol. 2009 Jul;35(7):1148-58. doi: 10.1016/j.ultrasmedbio.2008.11.014. Epub 2009 Apr 25.
3
Fibrin targeting of echogenic liposomes with inactivated tissue plasminogen activator.用灭活的组织纤溶酶原激活剂对回声脂质体进行纤维蛋白靶向
J Liposome Res. 2008;18(2):95-112. doi: 10.1080/08982100802118482.
4
Characterization of ultrasound propagation through ex-vivo human temporal bone.超声在离体人颞骨中传播的特性研究
Ultrasound Med Biol. 2008 Oct;34(10):1578-89. doi: 10.1016/j.ultrasmedbio.2008.02.012. Epub 2008 May 23.
5
Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent.使用Definity作为空化成核剂的超声增强溶栓治疗。
Ultrasound Med Biol. 2008 Sep;34(9):1421-33. doi: 10.1016/j.ultrasmedbio.2008.01.016. Epub 2008 Apr 18.
6
An improved theory for the prediction of microcavitation thresholds.一种用于预测微空化阈值的改进理论。
IEEE Trans Ultrason Ferroelectr Freq Control. 1989;36(2):204-8. doi: 10.1109/58.19152.
7
In vitro detection of cavitation induced by a diagnostic ultrasound system.诊断超声系统诱导空化的体外检测。
IEEE Trans Ultrason Ferroelectr Freq Control. 1992;39(1):95-101. doi: 10.1109/58.166815.
8
Effective and safe conditions of low-frequency transcranial ultrasonic thrombolysis for acute ischemic stroke: neurologic and histologic evaluation in a rat middle cerebral artery stroke model.急性缺血性卒中低频经颅超声溶栓的有效及安全条件：大鼠大脑中动脉卒中模型的神经学和组织学评估
Stroke. 2008 Mar;39(3):1007-11. doi: 10.1161/STROKEAHA.107.496117. Epub 2008 Jan 31.
9
Cavitational mechanisms in ultrasound-accelerated fibrinolysis.超声加速纤维蛋白溶解中的空化机制。
Ultrasound Med Biol. 2007 Jun;33(6):924-33. doi: 10.1016/j.ultrasmedbio.2006.11.022. Epub 2007 Apr 16.
10
Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes.使用负载组织型纤溶酶原激活剂的回声脂质体进行超声辅助溶栓。
Thromb Res. 2007;119(6):777-84. doi: 10.1016/j.thromres.2006.06.009. Epub 2006 Aug 2.

超声辅助溶栓治疗脑卒中：气泡有助于更好地分解血栓。

Ultrasound-assisted thrombolysis for stroke therapy: better thrombus break-up with bubbles.

机构信息

Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45267-0586, USA.

出版信息

Stroke. 2010 Oct;41(10 Suppl):S50-3. doi: 10.1161/STROKEAHA.110.595348.

DOI:10.1161/STROKEAHA.110.595348
PMID:20876505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2955362/
Abstract

BACKGROUND AND PURPOSE

Ultrasound has been shown to increase recombinant tissue plasminogen activator thrombolysis through stable cavitation, or sustained bubble activity, but this mechanism needs further optimization. Use of low-frequency ultrasound in combination with microbubbles stabilized against dissolution, in the form of ultrasound contrast agents, has resulted in greater lytic efficacy in vitro. Summary of Review-This article reviews the motivation for developing ultrasound-enhanced thrombolysis and the existing evidence for its potential as an intervention for ischemic stroke. Stable cavitation is discussed and current in vitro and ex vivo studies of bubble-mediated recombinant tissue plasminogen activator clot lysis are summarized.

CONCLUSIONS

Ultrasound-driven stable cavitation nucleated by an infusion of an echo contrast agent facilitates recombinant tissue plasminogen activator thrombolysis. Optimization of this gently effervescent phenomenon has the potential to reduce the morbidity and mortality of victims of ischemic stroke.

摘要

背景与目的

超声通过稳定空化或持续的气泡活动，已被证明可以增加重组组织型纤溶酶原激活剂溶栓效果，但这种机制需要进一步优化。低频超声与微泡联合使用，以超声对比剂的形式稳定，可在体外获得更大的溶解效果。综述总结-本文综述了开发超声增强溶栓的动机，以及其作为缺血性脑卒中干预手段的潜在价值。讨论了稳定空化，并总结了目前关于气泡介导的重组组织型纤溶酶原激活剂血栓溶解的体外和离体研究。结论：输注超声造影剂引发的超声驱动稳定空化有助于重组组织型纤溶酶原激活剂溶栓。这种温和的沸腾现象的优化有可能降低缺血性脑卒中患者的发病率和死亡率。