Sekar N, Kanthasamy A, William S, Balasubramaniyan N, Govindasamy S
Department of Biochemistry, University of Madras, India.
Acta Diabetol Lat. 1990 Oct-Dec;27(4):285-93. doi: 10.1007/BF02580932.
The activities of enzymes involved in cellular defence mechanisms such as superoxide dismutase, catalase, glutathione peroxidase and glutathione level have been found to be altered in experimental diabetes. Rats were made diabetic by a single i.v. injection of streptozotocin (55 mg/kg body weight) in citrate buffer. After the onset of diabetes, the diabetic rats were treated with sodium orthovanadate (0.3 mg/ml) for 15 days. Decreased activities of glutathione peroxidase, catalase, superoxide dismutase and glutathione content found in diabetic rats were corrected to near normal. The altered levels of plasma lipid peroxide, glycoproteins and erythrocyte membrane phospholipids in diabetic rats were restored to control levels by vanadate treatment. These observations clearly indicate the antioxidant potential of vanadate on experimental diabetes.
在实验性糖尿病中，参与细胞防御机制的酶如超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶的活性以及谷胱甘肽水平都发生了改变。通过在柠檬酸盐缓冲液中单次静脉注射链脲佐菌素（55毫克/千克体重）使大鼠患糖尿病。糖尿病发病后，用原钒酸钠（0.3毫克/毫升）治疗糖尿病大鼠15天。糖尿病大鼠中谷胱甘肽过氧化物酶、过氧化氢酶、超氧化物歧化酶活性降低以及谷胱甘肽含量降低的情况被纠正至接近正常水平。糖尿病大鼠血浆脂质过氧化物、糖蛋白和红细胞膜磷脂水平的改变通过钒酸盐治疗恢复到对照水平。这些观察结果清楚地表明了钒酸盐对实验性糖尿病的抗氧化潜力。
