Bucci Raffaella, Georgilis Evangelos, Bittner Alexander M, Gelmi Maria L, Clerici Francesca
Department of Pharmaceutical Sciences, University of Milan, Via Venezian 21, 20133 Milan, Italy.
CIC nanoGUNE, (BRTA) Tolosa Hiribidea 76, 20018 Donostia-San Sebastián, Spain.
Nanomaterials (Basel). 2021 May 11;11(5):1262. doi: 10.3390/nano11051262.
Electrospinning is a well-known, straightforward, and versatile technique, widely used for the preparation of fibers by electrifying a polymer solution. However, a high molecular weight is not essential for obtaining uniform electrospun fibers; in fact, the primary criterion to succeed is the presence of sufficient intermolecular interactions, which function similar to chain entanglements. Some small molecules able to self-assemble have been electrospun from solution into fibers and, among them, peptides containing both natural and non-natural amino acids are of particular relevance. Nowadays, the use of peptides for this purpose is at an early stage, but it is gaining more and more interest, and we are now witnessing the transition from basic research towards applications. Considering the novelty in the relevant processing, the aim of this review is to analyze the state of the art from the early 2000s on. Moreover, advantages and drawbacks in using peptides as the main or sole component for generating electrospun nanofibers will be discussed. Characterization techniques that are specifically targeted to the produced peptide fibers are presented.
静电纺丝是一种广为人知、简单且通用的技术，广泛用于通过使聚合物溶液带电来制备纤维。然而，高分子量对于获得均匀的静电纺丝纤维并非必不可少；事实上，成功的主要标准是存在足够的分子间相互作用，其作用类似于链缠结。一些能够自组装的小分子已从溶液中静电纺丝成纤维，其中，含有天然和非天然氨基酸的肽尤为重要。如今，将肽用于此目的尚处于早期阶段，但越来越受到关注，我们正在见证从基础研究向应用的转变。鉴于相关加工的新颖性，本综述的目的是分析21世纪初以来的现有技术水平。此外，还将讨论使用肽作为主要或唯一成分来制备静电纺丝纳米纤维的优缺点。介绍了专门针对所生产的肽纤维的表征技术。
