Liu E-Hu, Qi Lian-Wen, Li Kai, Chu Chu, Li Ping
Key Laboratory of Modern Chinese Medicines, (China Pharmaceutical University), Ministry of Education, No. 24 Tongjia Lane, Nanjing 210009, China.
Comb Chem High Throughput Screen. 2010 Dec;13(10):869-84. doi: 10.2174/138620710793360301.
Traditional Chinese medicines (TCMs) have been used for disease prevention and therapy in China for a long time and are becoming increasingly popular over the world. However, TCMs are complex mixtures and contain usually hundreds of chemically different constituents, which make the quality control of crude drugs and their medical preparations extremely difficult. Therefore, better analytical strategies to assure their efficacy, safety and consistency are in great demand. The present work provides an overview of the development of quality control for TCMs based on microscopic and molecular identification, quantitative and qualitative analysis, fingerprint, combination of fingerprint and multi-component quantification, as well as activity-integrated fingerprint over the last five years. The biological fingerprinting analysis of TCMs with targeting absorption, distribution, metabolism, excretion by chromatographic and chemometric method are also highlighted due to its broad application in the quality control of TCMs. The comprehensive methods analyzed with modern hyphenated techniques are strongly recommended to assess the authenticity, quality consistency and stability of TCMs.
中药在中国用于疾病预防和治疗已有很长时间，并且在世界范围内越来越受欢迎。然而，中药是复杂的混合物，通常含有数百种化学性质不同的成分，这使得中药材及其制剂的质量控制极其困难。因此，迫切需要更好的分析策略来确保其有效性、安全性和一致性。本工作概述了过去五年中基于微观和分子鉴定、定量和定性分析、指纹图谱、指纹图谱与多成分定量相结合以及活性整合指纹图谱的中药质量控制发展情况。由于其在中药质量控制中的广泛应用，还重点介绍了采用色谱和化学计量学方法对中药进行靶向吸收、分布、代谢、排泄的生物指纹图谱分析。强烈建议采用现代联用技术进行综合分析，以评估中药的真伪、质量一致性和稳定性。
