Pathology Queensland, Townsville Hospital, Townsville, Queensland, Australia.
Am J Trop Med Hyg. 2010 Oct;83(4):876-8. doi: 10.4269/ajtmh.2010.10-0237.
The aim of this study was to define the clinical presentation of brucellosis in northern Australia and to assess the long-term impact of brucellosis on individual lives. A retrospective review was conducted to assess 32 patients with brucellosis caused by Brucella suis in Townsville, Australia during 1996-2009. All patients were Caucasian males with a mean age of 35 years. The greatest risk factor for brucellosis was feral pig hunting (94%, n = 30). There was one laboratory-acquired case. The most frequent clinical features included fever (94%, n = 30), fatigue (78%, n = 25) and arthralgia (78%, n = 25). The complication rate was 25% (n = 8). A delay in diagnosis of more than 14 days significantly increased the risk of the patient developing complications (95% confidence interval = 3.20-198.96, P = 0.002). The long-term impact of brucellosis was significant; 64% (16) of the patients reporting recurrent symptoms. This study highlights the need for further research on brucellosis caused by B. suis.
本研究旨在定义北澳地区布鲁氏菌病的临床特征，并评估布鲁氏菌病对个体生活的长期影响。我们对 1996 年至 2009 年期间澳大利亚汤斯维尔因感染猪种布鲁氏菌而罹患布鲁氏菌病的 32 例患者进行了回顾性分析。所有患者均为白人男性，平均年龄 35 岁。猎食野猪是感染布鲁氏菌病的最大风险因素（94%，n=30）。有一例实验室感染病例。最常见的临床特征包括发热（94%，n=30）、乏力（78%，n=25）和关节炎（78%，n=25）。并发症发生率为 25%（n=8）。诊断延误超过 14 天显著增加了患者发生并发症的风险（95%置信区间=3.20-198.96，P=0.002）。布鲁氏菌病的长期影响显著，64%（16 例）的患者报告出现反复症状。本研究强调了进一步研究猪种布鲁氏菌引起的布鲁氏菌病的必要性。
