Gao Shuanhu, Wang Qiaoling, Wang Gelin, Lomenick Brett, Liu Jie, Fan Chih-Wei, Deng Lih-Wen, Huang Jing, Lum Lawrence, Chen Chuo
Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Synlett. 2012 Oct;16(23):2298-2310. doi: 10.1055/s-0031-1290460.
Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.
从导致珊瑚黑带病的海绵星状扁海绵（Terpios hoshinota）中分离得到的纳奇萜菌素，是从海洋来源发现的首个C-去甲-D-高甾体。我们在此介绍中概述了这种天然产物的化学和生物学特性。我们还包括了C-去甲-D-高甾体合成的简短历史以及一些关于纳奇萜菌素未发表的生物学研究结果。
