最初：产生神经嵴细胞多样性。
In the beginning: Generating neural crest cell diversity.
机构信息
Institute of Opthalmology, University College London.
出版信息
Cell Adh Migr. 2010 Oct-Dec;4(4):622-30. doi: 10.4161/cam.4.4.13502.
Abstract
Neural crest cells (NCCs) are migratory cells that delaminate from the neural tube early in development and then disseminate throughout the embryo to give rise to a wide variety of cell types that are key to the vertebrate body plan. During their journey from the neural tube to their peripheral targets, NCCs progressively differentiate, raising the question when the fate of an individual NCC is sealed. One hypothesis suggests that the fate of a NCC is specified by target-derived signals emanating from the environment they migrate through, while another hypothesis proposes that NCCs are already specified to differentiate along select lineages at the time they are born in the neural tube, with environmental signals helping them to realize their prespecified fate potential. Alternatively, both mechanisms may cooperate to drive NCC diversity. This review highlights recent advances in our understanding of prespecification during trunk NCC development.
摘要
神经嵴细胞（NCCs）是在胚胎发育早期从神经管分离出来的迁移细胞，然后散布到整个胚胎中，产生各种细胞类型，这些细胞类型是脊椎动物体计划的关键。在从神经管到其周围靶标的迁移过程中，NCC 逐渐分化，提出了一个问题，即单个 NCC 的命运何时被确定。一种假设认为，NCC 的命运是由它们迁移所经过的环境中产生的靶标衍生信号决定的，而另一种假设则提出，NCC 从出生在神经管时就已经被指定沿着特定的谱系分化，环境信号帮助它们实现预先指定的命运潜力。或者，这两种机制可能共同合作来驱动 NCC 多样性。这篇综述强调了我们对躯干 NCC 发育过程中预先指定的理解的最新进展。
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