母体磷脂酰肌醇 3-激酶信号通路对于胚胎基因组激活和植入前胚胎发生至关重要。
Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis.
机构信息
Department of Medical Biochemistry & Biophysics, Umeå University, Umeå, Sweden.
出版信息
EMBO Rep. 2010 Nov;11(11):890-5. doi: 10.1038/embor.2010.144. Epub 2010 Oct 8.
Abstract
Maternal effect factors derived from oocytes are important for sustaining early embryonic development before the major wave of embryonic genome activation (EGA). In this study, we report a two-cell-stage arrest of embryos lacking maternal 3-phosphoinositide-dependent protein kinase 1 as a result of suppressed EGA. Concurrent deletion of maternal Pten completely rescued the suppressed EGA and embryonic progression through restored AKT signalling, which fully restored the fertility of double-mutant females. Our study identifies maternal phosphatidylinositol 3-kinase signalling as a new maternal effect factor that regulates EGA and preimplantation embryogenesis in mice.
摘要
卵母细胞衍生的母体效应因子对于在胚胎基因组激活（EGA）的主要波之前维持早期胚胎发育很重要。在这项研究中，我们报道了缺乏母源 3-磷酸肌醇依赖性蛋白激酶 1 的胚胎在 EGA 被抑制后处于两细胞期停滞。母源 Pten 的同时缺失完全挽救了被抑制的 EGA 和胚胎发育，通过恢复 AKT 信号，这完全恢复了双突变雌性的生育能力。我们的研究确定了母源磷脂酰肌醇 3-激酶信号作为一种新的母体效应因子，调节小鼠的 EGA 和植入前胚胎发生。
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