FORMI (Communication Unit for Musculoskeletal Disorders), Oslo University Hospital, Ullevaal, Oslo, Norway National Resource Centre for Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway Arthritis Research UK Primary Care Centre, Keele University, UK.
Pain. 2010 Dec;151(3):790-797. doi: 10.1016/j.pain.2010.09.014. Epub 2010 Oct 6.
Few studies have investigated whether prognostic indicators, which contribute to the transition from acute to chronic low back pain (LBP), are also those which contribute to continuing persistence of chronic LBP. We compared the contribution of physical, psychological and social indicators to predicting disability after one year between consulters with LBP of less than 3 months duration and more than 3 months duration. Data from two large prospective cohort studies of consecutive patients consulting with LBP in general practices were merged, providing complete data for 258 cases with acute/subacute LBP and 668 cases with chronic LBP at 12 months follow-up. There were significant differences between the two LBP groups in baseline characteristics and clinical course of disability, assessed by Roland Morris Disability Questionnaire, during the year of follow-up. Adjusted associations between potential prognostic indicators and disability at 12months were carried out in the two LBP subgroups. The final multivariable regression models showed that being non-employed, having widespread pain, a high level of Chronic Pain Grade, and catastrophising were the strongest prognostic indicators for disability at 12 months in both LBP groups. Fear of pain was significantly associated with disability in chronic LBP. Importantly, beyond baseline disability, the effect size of the other prognostic indicators for poor outcome was rather low. These findings must continue to challenge researchers to identify useful early predictors of outcome in persons with disabling back pain, as screening and targeted treatment approaches are dependent upon prognostic indicators with clinical significance.
很少有研究调查预后指标是否有助于从急性转为慢性下腰痛(LBP),也没有研究调查这些预后指标是否有助于慢性 LBP 的持续存在。我们比较了身体、心理和社会指标对预测急性/亚急性 LBP 持续时间<3 个月和>3 个月的患者在 1 年后残疾的作用。合并了两项关于连续就诊于普通诊所的 LBP 患者的大型前瞻性队列研究的数据,为 258 例急性/亚急性 LBP 和 668 例慢性 LBP 的 12 个月随访提供了完整的数据。在 1 年的随访期间,根据 Roland Morris 残疾问卷评估的基线特征和残疾的临床病程,两组 LBP 患者之间存在显著差异。在两个 LBP 亚组中进行了潜在预后指标与 12 个月残疾之间的调整关联分析。最终的多变量回归模型显示,在两个 LBP 组中,失业、广泛疼痛、慢性疼痛分级高和灾难化是残疾的最强预后指标。在慢性 LBP 中,对疼痛的恐惧与残疾显著相关。重要的是,除了基线残疾,其他预后指标对不良结局的影响大小相当低。这些发现必须继续挑战研究人员,以确定有残疾腰痛患者的有用早期预后预测因子,因为筛查和针对性治疗方法取决于具有临床意义的预后指标。