Division of Veterinary Pathology, Infection and Immunity, School of Veterinary Science, University of Bristol, Langford House, Langford, North Somerset, UK.
Microbes Infect. 2011 Jan;13(1):42-8. doi: 10.1016/j.micinf.2010.09.007. Epub 2010 Oct 8.
Campylobacter jejuni and Campylobacter coli together represent the leading bacterial cause of human enteritis. However, the pathogenesis of this disease is poorly understood. Infection results in the formation of crypt abscesses resulting from the migration of neutrophils across the intestinal epithelium and into the intestinal crypts. In this study, we model this process in vitro and show that Campylobacter infection of epithelium results in a quantifiable increase in the directed movement of neutrophils from the basolateral to apical surface of the epithelium. This process is dependent on both bacterially derived n-formyl peptides and on the host cell enzyme 12-lipoxygenase (12-LOX).
空肠弯曲菌和结肠弯曲菌共同构成了人类肠炎的主要细菌性病因。然而，这种疾病的发病机制还不清楚。感染会导致隐窝脓肿的形成，这是由于中性粒细胞穿过肠上皮并迁移到肠隐窝中引起的。在这项研究中，我们在体外模拟了这一过程，并表明空肠弯曲菌感染上皮会导致中性粒细胞从上皮的基底侧向顶侧向的定向运动明显增加。这个过程既依赖于细菌衍生的甲酰肽，也依赖于宿主细胞酶 12-脂氧合酶（12-LOX）。
