Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan; Department of Occupational Health "Clinica del Lavoro Luigi Devoto", Section of Medical Statistics "Giulio A. Maccacaro", Università degli Studi di Milano, Milan.
Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan; Department of Otorhinolaryngology, Università degli Studi di Milano-Bicocca, Monza, Italy.
Ann Oncol. 2011 Mar;22(3):536-544. doi: 10.1093/annonc/mdq603. Epub 2010 Oct 13.
Data of epidemiological studies on the relation between coffee drinking and upper aerodigestive tract cancer risk are scattered and inconclusive. We therefore conducted systematic meta-analyses of observational studies published before October 2009.
We combined relative risks (RR) with 95% confidence intervals (CI) for cancers of the oral cavity/pharynx (OP) and larynx, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), comparing the highest versus the lowest categories of coffee consumption, using random-effects models.
For OP cancer, the pooled RR was 0.64 (95% CI 0.51-0.80) for highest versus lowest coffee drinking, based on a total of 2633 cases from one cohort and eight case-control studies, with no significant heterogeneity across studies. The RRs were 0.61 (95% CI 0.41-0.89) for European, 0.58 (95% CI 0.36-0.94) for American and 0.74 (95% CI 0.48-1.15) for Asian studies, where coffee consumption is lower. The corresponding RRs were 1.56 (95% CI 0.60-4.02) for laryngeal cancer (732 cases from three case-control studies), 0.87 (95% CI 0.65-1.17) for ESCC (2115 cases from one cohort and six case-control studies) and 1.18 (95% CI 0.81-1.71) for EAC (415 cases from three case-control studies).
Coffee drinking is inversely related to OP cancer risk, while there is no relation with laryngeal cancer, ESCC and EAC.
关于喝咖啡与上呼吸道和消化道癌症风险之间关系的流行病学研究数据较为分散且结论并不明确。因此，我们对 2009 年 10 月之前发表的观察性研究进行了系统的荟萃分析。
我们采用随机效应模型，将口腔/咽癌（OP）和喉癌、食管鳞癌（ESCC）和食管腺癌（EAC）的相对风险（RR）与 95%置信区间（CI）相结合，比较了最高和最低咖啡摄入量组的风险。
共有一项队列研究和八项病例对照研究，共纳入 2633 例 OP 癌症患者，基于此，我们发现最高咖啡摄入量组的 RR 为 0.64（95%CI 0.51-0.80），组间无显著异质性。欧洲、美国和亚洲的 RR 分别为 0.61（95%CI 0.41-0.89）、0.58（95%CI 0.36-0.94）和 0.74（95%CI 0.48-1.15），这些地区的咖啡摄入量较低。相应的 RR 分别为 1.56（95%CI 0.60-4.02）（三项病例对照研究共纳入 732 例喉癌患者）、0.87（95%CI 0.65-1.17）（一项队列研究和六项病例对照研究共纳入 2115 例 ESCC 患者）和 1.18（95%CI 0.81-1.71）（三项病例对照研究共纳入 415 例 EAC 患者）。
咖啡的摄入与 OP 癌症风险呈负相关，而与喉癌、ESCC 和 EAC 无关。
