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用于磁导向和内容物释放的细菌生物杂交体的微流体制备

Microfluidic generation of bacterial biohybrids for magnetic guidance and content release.

作者信息

O'Toole Nina, Allen Matthew E, Contini Claudia, Elani Yuval

机构信息

Department of Chemical Engineering, Imperial College London, South Kensington, London SW7 2AZ, UK.

Institute of Chemical Biology, Imperial College London, Molecular Sciences Research Hub, London, W12 0BZ, UK.

出版信息

Chem Commun (Camb). 2025 Jul 14. doi: 10.1039/d5cc00449g.

DOI:10.1039/d5cc00449g
PMID:40657802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12257921/
Abstract

Bacterial biohybrids use bacterial and synthetic components for biotechnological applications. Here, we outline an adaptable and high-throughput microfluidic platform to create microscale biocontained bacterial biohybrids enclosed in a hydrogel with magnetotactic and biosensing properties. The biohybrids are capable of magnetically driven motility, biochemical sensing and controlled cargo release. This approach enables the scalable fabrication of biocontained multifunctional biohybrids for potential industrial and biomedical applications.

摘要

细菌生物杂交体利用细菌和合成成分用于生物技术应用。在此，我们概述了一种适应性强且高通量的微流控平台，用于创建包裹在具有趋磁和生物传感特性的水凝胶中的微型生物包含细菌生物杂交体。这些生物杂交体能够进行磁驱动运动、生化传感和可控的货物释放。这种方法能够可扩展地制造用于潜在工业和生物医学应用的生物包含多功能生物杂交体。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c2/12257921/7a290fc5f220/d5cc00449g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c2/12257921/be61e7ee374d/d5cc00449g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c2/12257921/d6852538448e/d5cc00449g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c2/12257921/7a290fc5f220/d5cc00449g-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c2/12257921/be61e7ee374d/d5cc00449g-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c2/12257921/d6852538448e/d5cc00449g-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4c2/12257921/7a290fc5f220/d5cc00449g-f3.jpg

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Microfluidic generation of bacterial biohybrids for magnetic guidance and content release.

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本文引用的文献

[1]
Bacterial therapies at the interface of synthetic biology and nanomedicine.

Nat Rev Bioeng. 2024-2

[2]
Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions.

Signal Transduct Target Ther. 2024-7-1

[3]
Engineered Bacteria as Living Biosensors in Dermal Tattoos.

Adv Sci (Weinh). 2024-8

[4]
Biomimetic behaviors in hydrogel artificial cells through embedded organelles.

Proc Natl Acad Sci U S A. 2023-8-29

[5]
Hydrogels as functional components in artificial cell systems.

Nat Rev Chem. 2022-8

[6]
Bioprinting microporous functional living materials from protein-based core-shell microgels.

Nat Commun. 2023-1-19

[7]
Hierarchical encapsulation of bacteria in functional hydrogel beads for inter- and intra- species communication.

Acta Biomater. 2023-3-1

[8]
Biohybrid robots: recent progress, challenges, and perspectives.

Bioinspir Biomim. 2022-11-8

[9]
Magnetic Living Hydrogels for Intestinal Localization, Retention, and Diagnosis.

Adv Funct Mater. 2021-7-2

[10]
Biohybrid materials: Structure design and biomedical applications.

Mater Today Bio. 2022-7-8

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