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羧酸酯酶(CES)活性的测定。

Measurement of carboxylesterase (CES) activities.

作者信息

Hosokawa Masakiyo, Satoh Tetsuo

机构信息

Chiba University, Chiba, Japan.

出版信息

Curr Protoc Toxicol. 2002 Feb;Chapter 4:Unit4.7. doi: 10.1002/0471140856.tx0407s10.

DOI:10.1002/0471140856.tx0407s10
PMID:20945299
Abstract

Measurement of Carboxylesterase (CES) Activities (Masakiyo Hosokawa, Chiba University, Chiba, Japan and Tetsuo Satoh, Biomedical Research Institute, Chiba, Japan). Mammalian carboxyesterase (CES) efficiently catalyzes the hydrolysis of a variety of ester- and amide-containing chemicals. CES is involved in detoxification or metabolic activation of various drugs, environmental toxicants, and carcinogens. This unit contains three protocols for measuring CES activities.

摘要

羧酸酯酶(CES)活性的测定(细川正喜代,日本千叶大学,千叶,日本以及佐藤哲夫,日本千叶生物医学研究所)。哺乳动物羧酸酯酶(CES)能高效催化多种含酯和酰胺的化学物质的水解反应。CES参与多种药物、环境毒物及致癌物的解毒或代谢活化过程。本单元包含三种测定CES活性的实验方案。

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