为什么铜绿假单胞菌是一种病原体？
Why is Pseudomonas aeruginosa a pathogen?
作者信息
Goldberg Joanna B
机构信息
Department of Microbiology, University of Virginia Health System Box 800734, Charlottesville, VA 22908-0734 USA.
出版信息
F1000 Biol Rep. 2010 Apr 27;2:29. doi: 10.3410/B2-29.
Abstract
Despite the expression of a myriad of virulence factors, healthy individuals are generally able to resist infections with Pseudomonas aeruginosa. Polymorphonuclear leukocyte-dependent killing is the major mechanism responsible for resistance; dysregulation of host defense mechanisms in addition to expression of specific bacterial factors can result in life-threatening infections with this bacterium.
摘要
尽管铜绿假单胞菌表达了无数种毒力因子，但健康个体通常能够抵抗该菌的感染。多形核白细胞依赖性杀伤是抵抗感染的主要机制；除了特定细菌因子的表达外，宿主防御机制失调也可导致该菌引发危及生命的感染。
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