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Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies.铜绿假单胞菌生物膜感染囊性纤维化：对发病机制和治疗策略的深入了解。
Expert Opin Ther Targets. 2010 Feb;14(2):117-30. doi: 10.1517/14728220903454988.
2
Cystic fibrosis neutrophils have normal intrinsic reactive oxygen species generation.囊性纤维化中性粒细胞具有正常的固有活性氧物种生成。
Eur Respir J. 2010 Jun;35(6):1264-72. doi: 10.1183/09031936.00089709. Epub 2009 Oct 19.
3
Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia.中性粒细胞作为急性铜绿假单胞菌肺炎细胞固有免疫介质的不可或缺性。
Infect Immun. 2009 Dec;77(12):5300-10. doi: 10.1128/IAI.00501-09. Epub 2009 Oct 5.
4
Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses.肺炎链球菌和铜绿假单胞菌肺炎引起不同的宿主反应。
Crit Care Med. 2010 Jan;38(1):223-41. doi: 10.1097/CCM.0b013e3181b4a76b.
5
Shielding, a new pathogen defence mechanism against PMNs.屏蔽，一种针对中性粒细胞的新型病原体防御机制。
Microbiology (Reading). 2009 Nov;155(Pt 11):3474-3475. doi: 10.1099/mic.0.033969-0. Epub 2009 Sep 3.
6
Targeting a bacterial stress response to enhance antibiotic action.靶向细菌应激反应以增强抗生素作用。
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7
Comparative transcriptome analyses of Pseudomonas aeruginosa.铜绿假单胞菌的比较转录组分析
Hum Genomics. 2009 Jul;3(4):349-61. doi: 10.1186/1479-7364-3-4-361.
8
Extracellular DNA and F-actin as targets in antibiofilm cystic fibrosis therapy.
Future Microbiol. 2009 Aug;4(6):645-7. doi: 10.2217/fmb.09.38.
9
Pseudomonas aeruginosa recognizes and responds aggressively to the presence of polymorphonuclear leukocytes.铜绿假单胞菌能够识别多形核白细胞的存在，并对其做出强烈反应。
Microbiology (Reading). 2009 Nov;155(Pt 11):3500-3508. doi: 10.1099/mic.0.031443-0. Epub 2009 Jul 30.
10
Inactivation of the rhlA gene in Pseudomonas aeruginosa prevents rhamnolipid production, disabling the protection against polymorphonuclear leukocytes.铜绿假单胞菌中rhlA基因的失活会阻止鼠李糖脂的产生，从而使对多形核白细胞的保护失效。
APMIS. 2009 Jul;117(7):537-46. doi: 10.1111/j.1600-0463.2009.02466.x.

为什么铜绿假单胞菌是一种病原体？

Why is Pseudomonas aeruginosa a pathogen?

作者信息

Goldberg Joanna B

机构信息

Department of Microbiology, University of Virginia Health System Box 800734, Charlottesville, VA 22908-0734 USA.

出版信息

F1000 Biol Rep. 2010 Apr 27;2:29. doi: 10.3410/B2-29.

DOI:10.3410/B2-29
PMID:20948804
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2948353/
Abstract

Despite the expression of a myriad of virulence factors, healthy individuals are generally able to resist infections with Pseudomonas aeruginosa. Polymorphonuclear leukocyte-dependent killing is the major mechanism responsible for resistance; dysregulation of host defense mechanisms in addition to expression of specific bacterial factors can result in life-threatening infections with this bacterium.

摘要

尽管铜绿假单胞菌表达了无数种毒力因子，但健康个体通常能够抵抗该菌的感染。多形核白细胞依赖性杀伤是抵抗感染的主要机制；除了特定细菌因子的表达外，宿主防御机制失调也可导致该菌引发危及生命的感染。