伊朗伊斯法罕住院患者铜绿假单胞菌分离株的抗菌药敏性及Ⅰ类和Ⅱ类整合子研究
Investigation of antimicrobial susceptibility, class I and II integrons among Pseudomonas aeruginosa isolates from hospitalized patients in Isfahan, Iran.
作者信息
Faghri Jamshid, Nouri Samereh, Jalalifar Saba, Zalipoor Mehrdad, Halaji Mehrdad
机构信息
Department of Microbiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Microbiology, Clinical Laboratory of ALZAHRA Medical Center, Isfahan, Iran.
出版信息
BMC Res Notes. 2018 Nov 12;11(1):806. doi: 10.1186/s13104-018-3901-9.
OBJECTIVES
The role of integrons in the transfer of antibiotic resistance is one of the important issues, therefore, this study is aimed to investigate antibiotic resistance pattern and prevalence of class 1 and 2 integrons in P. aeruginosa isolated.
RESULTS
Out of 72 confirmed P. aeruginosa isolates, 50% were from ICU patients. Antibacterial susceptibility pattern showed that isolates were most resistant to ceftazidime (76.4%) and colistin was the most effective antibiotic (100%) and molecular analysis of class I and II integrons showed 55.5% and 29.1% of isolates were positive, respectively and the proportions of MDR isolates were significantly higher among integron-positive isolates with 73.6% compared to negative isolates with 22.9%. Our results showed that there was a correlation among class 1 and 2 integrons with MDR P. aeruginosa isolates. According to the importance of integrons in acquisition and dissemination of antibiotics resistance genes, the performance of antibiotic surveillance programs and investigating the role of integrons is recommended to control the spreading of antibiotics resistance genes.
目的
整合子在抗生素耐药性转移中的作用是重要问题之一，因此，本研究旨在调查分离出的铜绿假单胞菌的抗生素耐药模式以及1类和2类整合子的流行情况。
结果
在72株确诊的铜绿假单胞菌分离株中，50%来自重症监护病房患者。抗菌药敏模式显示，分离株对头孢他啶耐药性最高（76.4%），而黏菌素是最有效的抗生素（100%），对I类和II类整合子的分子分析显示，分别有55.5%和29.1%的分离株呈阳性，整合子阳性分离株中的多重耐药分离株比例显著高于阴性分离株，分别为73.6%和22.9%。我们的结果表明，1类和2类整合子与多重耐药铜绿假单胞菌分离株之间存在相关性。鉴于整合子在抗生素耐药基因获取和传播中的重要性，建议开展抗生素监测计划并调查整合子的作用，以控制抗生素耐药基因的传播。
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