Epler Gary R
Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School 75 Francis Street, Boston, MA 02115 USA.
F1000 Med Rep. 2010 Apr 27;2:32. doi: 10.3410/M2-32.
Constrictive bronchiolitis is a bronchiolar airway disease that surrounds the lumen with fibrotic concentric narrowing and obliteration. The mosaic pattern seen on the expiratory high-resolution chest CT scan is diagnostic in an individual with shortness of breath, early inspiratory crackles, and irreversible airflow obstruction. Swyer-James-MacLeod syndrome is no longer considered a congenital disorder but as constrictive bronchiolitis detected in young adults who had infectious pneumonia during infancy. For lung transplant recipients, tacrolimus continues to be an important immune suppression medication, extracorporeal photopheresis may improve the decline of pulmonary function, and azithromycin may be effective in some lung transplant recipients for treatment of bronchiolitis obliterans syndrome for prevention of constrictive bronchiolitis.
缩窄性细支气管炎是一种细支气管气道疾病，其管腔被纤维化的同心性狭窄和闭塞所环绕。呼气期高分辨率胸部CT扫描上出现的马赛克征，对于有气短、早期吸气性啰音和不可逆气流受限的个体具有诊断意义。斯怀尔-詹姆斯-麦克劳德综合征不再被认为是一种先天性疾病，而是被视为在婴儿期患过感染性肺炎的年轻人中检测到的缩窄性细支气管炎。对于肺移植受者，他克莫司仍然是一种重要的免疫抑制药物，体外光化学疗法可能改善肺功能下降，阿奇霉素可能对一些肺移植受者治疗闭塞性细支气管炎综合征以预防缩窄性细支气管炎有效。
