Huynh Peter, Salam Muhammad T, Morphew Tricia, Kwong Kenny Y C, Scott Lyne
Division of Allergy and Immunology, Department of Pediatrics, Los Angeles County and University of Southern California Medical Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
J Allergy (Cairo). 2010;2010. doi: 10.1155/2010/157249. Epub 2010 Jun 13.
Background. Proximity to heavy traffic has been linked to increased asthma severity. However, it is unknown whether exposure to heavy traffic is associated with the ability to maintain asthma control. Objectives. This study examines whether exposure to heavy traffic is associated with the ability to maintain asthma control in inner-city children. Methods. 756 inner-city asthmatic Hispanic children were followed for one year in a pediatric asthma management program (Breathmobile). At each scheduled visit, asthma specialist tracked patients' asthma severity and managed their asthma based on the NAEPP guidelines. The patients' residential distance from the nearest freeway was calculated based on residential address at study entry. Distance to nearest freeway was used as a surrogate marker for high exposure from traffic-related air pollutants. Results. Patients who lived near a freeway were significantly more likely to have asthma that was not well controlled (P = .03). Patients with intermittent and mild baseline severity have a two-fold increased risk of having asthma that is uncontrolled if they lived <2 miles from a freeway (OR = 2.2, P = .04). Conclusion. In children with asthma, residential proximity to freeways is associated with uncontrolled asthma.
背景。靠近繁忙交通与哮喘严重程度增加有关。然而，接触繁忙交通是否与维持哮喘控制的能力相关尚不清楚。目的。本研究调查接触繁忙交通是否与城市内儿童维持哮喘控制的能力相关。方法。756名城市内患有哮喘的西班牙裔儿童在一项儿科哮喘管理项目（呼吸流动车）中随访了一年。在每次预定访视时，哮喘专科医生跟踪患者的哮喘严重程度，并根据美国国家哮喘教育与预防计划（NAEPP）指南对其哮喘进行管理。根据研究开始时的居住地址计算患者住所与最近高速公路的距离。到最近高速公路的距离被用作交通相关空气污染物高暴露的替代指标。结果。居住在高速公路附近的患者哮喘控制不佳的可能性显著更高（P = 0.03）。基线严重程度为间歇性和轻度的患者，如果居住在距离高速公路不到2英里处，哮喘未得到控制的风险会增加两倍（OR = 2.2，P = 0.04）。结论。在患有哮喘的儿童中，住所靠近高速公路与哮喘未得到控制有关。
