Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Am J Epidemiol. 2018 Jan 1;187(1):45-52. doi: 10.1093/aje/kwx223.
We examined traffic-related pollution (TRP) exposure and respiratory health effects in Hispanic white (HW) children, both compared with non-Hispanic white (NHW) children and according to genetically determined Native American (NA) ancestry. The sample included over 5,000 children from the Children's Health Study in California, followed during 1993-2014. HW children were 1.47 (95% confidence interval (CI): 1.24, 1.73) times more likely to live close (<500 m) to a freeway and 1.54 (95% CI: 1.26, 1.87) times more likely to live close (<75 m) to a major nonfreeway road compared with NHW children. Among HW children, those with >50% NA ancestry were >40% more likely to live close to a freeway or to a major nonfreeway road, compared with those with ≤50% NA ancestry. The association of TRP with ever having been diagnosed by a doctor as having asthma differed between HW and NHW children (P < 0.05), with the strongest association among HW children with >50% NA ancestry. Within this subgroup, those close to a major nonfreeway road were 2.16 (95% CI: 1.26, 3.69) times more likely to have ever reported asthma compared with those living further away. This paper provides evidence that HW children in southern California, especially those with greater NA ancestry, are more exposed to TRP and are potentially at greater risk for TRP-related respiratory health effects.
我们研究了交通相关污染(TRP)暴露和呼吸健康影响在西班牙裔白种人(HW)儿童中的作用,既与非西班牙裔白种人(NHW)儿童进行了比较,也根据遗传决定的美洲原住民(NA)血统进行了比较。该样本包括来自加利福尼亚州儿童健康研究的 5000 多名儿童,他们在 1993 年至 2014 年期间接受了随访。HW 儿童居住在高速公路附近(<500 米)的可能性是 NHW 儿童的 1.47 倍(95%置信区间(CI):1.24,1.73),居住在主要非高速公路附近(<75 米)的可能性是 NHW 儿童的 1.54 倍(95% CI:1.26,1.87)。在 HW 儿童中,与具有≤50%NA 血统的儿童相比,具有>50%NA 血统的儿童更有可能居住在高速公路或主要非高速公路附近。TRP 与医生诊断为哮喘的相关性在 HW 和 NHW 儿童之间存在差异(P<0.05),具有>50%NA 血统的 HW 儿童的相关性最强。在这个亚组中,与居住在较远地方的人相比,居住在主要非高速公路附近的人被诊断为哮喘的可能性要高出 2.16 倍(95% CI:1.26,3.69)。本文提供的证据表明,南加州的 HW 儿童,尤其是那些具有更大 NA 血统的儿童,更容易接触到 TRP,并且可能面临更大的 TRP 相关呼吸健康风险。