Bacher M, Linz A, Buchenau W, Arand J, Krimmel M, Poets C, Poets C
Zentrum für kindliche Fehlbildungen im Kiefer- und Gesichtsbereich (ZKFKG), Tübingen, Germany.
Laryngorhinootologie. 2010 Oct;89(10):621-9. doi: 10.1055/s-0030-1265140. Epub 2010 Oct 14.
The Pierre Robin sequence (PRS) characterized by mandibular micro- or retrognathia and glossoptosis with or without cleft palate, presents clinically with intermittent upper airway obstruction (UAO). It is associated with other malformations in about half the cases. The incidence is about 1:8,500. Isolated PRS without other malformations does not, by itself, appear to affect neurodevelopment. Active intervention may therefore be required to reduce the risk for neurocognitive impairment resulting from UAO. Current treatment options for UAO range from prone positioning, use of a nasopharyngeal tube, glossopexy via tongue lip adhesion, mandibular distraction to tracheostomy. An effective, non-invasive treatment protocol which includes implementation of an intraoral orthodontic appliance with velar extension (the pre-epiglottic baton plate; PEBP) is presented in this article.
皮埃尔·罗宾序列征（PRS）的特征为下颌骨发育不全或后缩以及舌后坠，伴或不伴有腭裂，临床上表现为间歇性上气道梗阻（UAO）。约半数病例伴有其他畸形。发病率约为1:8500。孤立性PRS且无其他畸形本身似乎不影响神经发育。因此，可能需要积极干预以降低UAO导致神经认知障碍的风险。目前针对UAO的治疗选择包括俯卧位、使用鼻咽管、通过舌唇粘连进行舌固定术、下颌骨牵张成骨至气管切开术。本文介绍了一种有效的非侵入性治疗方案，其中包括使用带有腭部延伸的口腔正畸矫治器（会厌前棒板；PEBP）。
