Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
J Interferon Cytokine Res. 2011 Jan;31(1):71-8. doi: 10.1089/jir.2010.0101. Epub 2010 Oct 15.
The ISG56/IFIT1 family of genes is clustered on human chromosome 10 and is comprised of 4 members, ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, and ISG58/IFIT5, whose homologs are evolutionarily conserved from mammals to amphibians. While these genes are normally silent in most cell types, their transcription is strongly induced by interferons, virus infection, and molecular patterns such as double-stranded RNA or lipopolysaccharides. The encoded P56 family proteins are characterized by multiple repeats of tetratricopeptide repeat helix-turn-helix motifs mediating a variety of protein-protein interactions, which result in a multitude of effects on cellular and viral functions, such as translation initiation, virus replication, double-stranded RNA signaling, cell migration, and proliferation.
ISG56/IFIT1 家族基因位于人类染色体 10 上，由 4 个成员组成，分别是 ISG56/IFIT1、ISG54/IFIT2、ISG60/IFIT3 和 ISG58/IFIT5，其同源物从哺乳动物到两栖动物在进化上都是保守的。虽然这些基因在大多数细胞类型中通常是沉默的，但它们的转录会被干扰素、病毒感染和双链 RNA 或脂多糖等分子模式强烈诱导。编码的 P56 家族蛋白的特征是多个串联重复的四肽重复螺旋-转角-螺旋基序介导多种蛋白质-蛋白质相互作用，从而对细胞和病毒功能产生多种影响，如翻译起始、病毒复制、双链 RNA 信号转导、细胞迁移和增殖。
