ISG56/IFIT1 基因家族。
The ISG56/IFIT1 gene family.
机构信息
Department of Molecular Genetics, The Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
出版信息
J Interferon Cytokine Res. 2011 Jan;31(1):71-8. doi: 10.1089/jir.2010.0101. Epub 2010 Oct 15.
Abstract
The ISG56/IFIT1 family of genes is clustered on human chromosome 10 and is comprised of 4 members, ISG56/IFIT1, ISG54/IFIT2, ISG60/IFIT3, and ISG58/IFIT5, whose homologs are evolutionarily conserved from mammals to amphibians. While these genes are normally silent in most cell types, their transcription is strongly induced by interferons, virus infection, and molecular patterns such as double-stranded RNA or lipopolysaccharides. The encoded P56 family proteins are characterized by multiple repeats of tetratricopeptide repeat helix-turn-helix motifs mediating a variety of protein-protein interactions, which result in a multitude of effects on cellular and viral functions, such as translation initiation, virus replication, double-stranded RNA signaling, cell migration, and proliferation.
摘要
ISG56/IFIT1 家族基因位于人类染色体 10 上，由 4 个成员组成，分别是 ISG56/IFIT1、ISG54/IFIT2、ISG60/IFIT3 和 ISG58/IFIT5，其同源物从哺乳动物到两栖动物在进化上都是保守的。虽然这些基因在大多数细胞类型中通常是沉默的，但它们的转录会被干扰素、病毒感染和双链 RNA 或脂多糖等分子模式强烈诱导。编码的 P56 家族蛋白的特征是多个串联重复的四肽重复螺旋-转角-螺旋基序介导多种蛋白质-蛋白质相互作用，从而对细胞和病毒功能产生多种影响，如翻译起始、病毒复制、双链 RNA 信号转导、细胞迁移和增殖。
相似文献
1
The ISG56/IFIT1 gene family.
J Interferon Cytokine Res. 2011 Jan;31(1):71-8. doi: 10.1089/jir.2010.0101. Epub 2010 Oct 15.
2
IFIT5 potentiates anti-viral response through enhancing innate immune signaling pathways.
Acta Biochim Biophys Sin (Shanghai). 2013 Oct;45(10):867-74. doi: 10.1093/abbs/gmt088. Epub 2013 Aug 13.
3
Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.
PLoS Pathog. 2012;8(5):e1002712. doi: 10.1371/journal.ppat.1002712. Epub 2012 May 17.
4
A death-promoting role for ISG54/IFIT2.
J Interferon Cytokine Res. 2013 Apr;33(4):199-205. doi: 10.1089/jir.2012.0159.
5
Interferon induced IFIT family genes in host antiviral defense.
Int J Biol Sci. 2013;9(2):200-8. doi: 10.7150/ijbs.5613. Epub 2013 Feb 11.
6
IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
Nucleic Acids Res. 2018 Jun 1;46(10):5269-5285. doi: 10.1093/nar/gky191.
7
ISG56/IFIT1 is primarily responsible for interferon-induced changes to patterns of parainfluenza virus type 5 transcription and protein synthesis.
J Gen Virol. 2013 Jan;94(Pt 1):59-68. doi: 10.1099/vir.0.046797-0. Epub 2012 Oct 10.
8
Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability.
Immunity. 2018 Mar 20;48(3):487-499.e5. doi: 10.1016/j.immuni.2018.01.014. Epub 2018 Mar 8.
9
Identification and expression analysis of the interferon-induced protein with tetratricopeptide repeats 5 (IFIT5) gene in duck (Anas platyrhynchos domesticus).
PLoS One. 2015 Mar 27;10(3):e0121065. doi: 10.1371/journal.pone.0121065. eCollection 2015.
10
Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.
J Biol Chem. 2016 Jun 24;291(26):13535-45. doi: 10.1074/jbc.M115.705467. Epub 2016 May 2.
引用本文的文献
1
Genetic resilience or resistance in poultry against avian influenza virus: mirage or reality?
J Virol. 2025 Jul 22;99(7):e0082025. doi: 10.1128/jvi.00820-25. Epub 2025 Jun 30.
2
Interferon-Stimulated Genes: Novel Targets in Renal Pathogenesis.
Kidney Dis (Basel). 2025 May 2;11(1):390-401. doi: 10.1159/000546141. eCollection 2025 Jan-Dec.
3
In vitro characterization of the antiviral activity of Bat Interferon-Induced protein with tetratricopeptide repeats 5 (bat IFIT5) against bat-associated rabies virus.
J Neurovirol. 2025 Feb 28. doi: 10.1007/s13365-025-01245-y.
4
Short 5' UTRs serve as a marker for viral mRNA translation inhibition by the IFIT2-IFIT3 antiviral complex.
bioRxiv. 2025 Feb 11:2025.02.11.637299. doi: 10.1101/2025.02.11.637299.
5
Evaluation of Genes and Molecular Pathways Common between Diffuse Large B-cell Lymphoma (DLBCL) and Systemic Lupus Erythematosus (SLE): A Systems Biology Approach.
Med J Islam Repub Iran. 2024 Nov 6;38:129. doi: 10.47176/mjiri.38.129. eCollection 2024.
6
An MST-based assay reveals new binding preferences of IFIT1 for canonically and noncanonically capped RNAs.
RNA. 2025 Jan 22;31(2):181-192. doi: 10.1261/rna.080089.124.
7
Antiviral Effects of Avian Interferon-Stimulated Genes.
Animals (Basel). 2024 Oct 24;14(21):3062. doi: 10.3390/ani14213062.
8
Diversity and structural-functional insights of alpha-solenoid proteins.
Protein Sci. 2024 Nov;33(11):e5189. doi: 10.1002/pro.5189.
9
Interferon-stimulated gene 56 positively regulates Toll-like receptor 3-mediated CXCL10 expression in human renal proximal tubular epithelial cells.
FEBS Open Bio. 2024 Aug;14(8):1303-1319. doi: 10.1002/2211-5463.13851. Epub 2024 Jun 23.
10
Cytosolic DNA sensors activation of human astrocytes inhibits herpes simplex virus through IRF1 induction.
Front Cell Infect Microbiol. 2024 May 14;14:1383811. doi: 10.3389/fcimb.2024.1383811. eCollection 2024.
本文引用的文献
1
High-throughput screening for TLR3-IFN regulatory factor 3 signaling pathway modulators identifies several antipsychotic drugs as TLR inhibitors.
J Immunol. 2010 May 15;184(10):5768-76. doi: 10.4049/jimmunol.0903559. Epub 2010 Apr 9.
2
Viral apoptosis is induced by IRF-3-mediated activation of Bax.
EMBO J. 2010 May 19;29(10):1762-73. doi: 10.1038/emboj.2010.50. Epub 2010 Apr 1.
3
Pattern recognition receptors and inflammation.
Cell. 2010 Mar 19;140(6):805-20. doi: 10.1016/j.cell.2010.01.022.
4
The interaction between interferon-induced protein with tetratricopeptide repeats-1 and eukaryotic elongation factor-1A.
Mol Cell Biochem. 2010 Apr;337(1-2):101-10. doi: 10.1007/s11010-009-0289-9. Epub 2009 Oct 24.
5
ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.
Proc Natl Acad Sci U S A. 2009 May 12;106(19):7945-50. doi: 10.1073/pnas.0900818106. Epub 2009 Apr 28.
6
IRF-9/STAT2 [corrected] functional interaction drives retinoic acid-induced gene G expression independently of STAT1.
Cancer Res. 2009 Apr 15;69(8):3673-80. doi: 10.1158/0008-5472.CAN-08-4922. Epub 2009 Apr 7.
7
Protein structure prediction on the Web: a case study using the Phyre server.
Nat Protoc. 2009;4(3):363-71. doi: 10.1038/nprot.2009.2.
8
Inducible deposition of the histone variant H3.3 in interferon-stimulated genes.
J Biol Chem. 2009 May 1;284(18):12217-25. doi: 10.1074/jbc.M805651200. Epub 2009 Feb 25.
9
Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.
EMBO J. 2008 Dec 17;27(24):3311-21. doi: 10.1038/emboj.2008.241. Epub 2008 Nov 13.
10
IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma.
Mol Cancer Res. 2008 Sep;6(9):1431-9. doi: 10.1158/1541-7786.MCR-08-0141.
Zotero 插件