Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Cidade Universitária, 50670-901, Recife, PE, Brazil.
Evid Based Complement Alternat Med. 2011;2011. doi: 10.1155/2011/692378. Epub 2010 Sep 19.
This paper reports the characterization of the antidiabetic role of a hydroethanolic extract from Parkinsonia aerial parts (HEPA), in normal and alloxan-induced diabetic rats, treated with HEPA (125 and 250 mg/kg; p.o.). Oral glucose tolerance test, acute oral toxicity test and preliminary phytochemical analyses were performed. The diabetic rats treated with HEPA showed a significant reduction in serum and urinary glucose, urinary urea and triglyceride levels, as compared to the diabetic untreated group. However, in the normal treated groups, a significant reduction was found only in serum triglyceride levels. In all treated diabetic groups, an improvement in hepatic glycogen was observed, as well as a decrease in liquid intake and urinary volume, and an enhancement in the weight of skeletal muscles (soleus and extensor digitorum longus), kidneys and epididymal adipose tissue. Nevertheless, body and liver weights were ameliorated only in the diabetic group treated with HEPA (250 mg/kg). Moreover, oral glucose tolerance was higher in animals treated with HEPA, while results also showed that HEPA could be considered toxicologically safe. Phytochemical analysis revealed the presence of tanins, flavonoids and steroids in HEPA. In conclusion, P. aculeata presents an antidiabetic activity and other beneficial effects that ameliorate diabetes and associated complications.
本文报道了从旱柳地上部分（HEPA）的水醇提取物中抗糖尿病作用的特征，在正常和链脲佐菌素诱导的糖尿病大鼠中，用 HEPA（125 和 250mg/kg；po）治疗。进行了口服葡萄糖耐量试验、急性口服毒性试验和初步的植物化学分析。与未治疗的糖尿病组相比，用 HEPA 治疗的糖尿病大鼠的血清和尿糖、尿尿素和甘油三酯水平显著降低。然而，在正常治疗组中，仅发现血清甘油三酯水平显著降低。在所有用 HEPA 治疗的糖尿病组中，观察到肝糖原增加，液体摄入和尿量减少，以及骨骼肌（比目鱼肌和趾长伸肌）、肾脏和附睾脂肪组织的重量增加。然而，仅在用 HEPA（250mg/kg）治疗的糖尿病组中，体重和肝重得到改善。此外，用 HEPA 治疗的动物的口服葡萄糖耐量更高，同时结果还表明 HEPA 可被认为是毒理学上安全的。植物化学分析表明 HEPA 中存在单宁、类黄酮和类固醇。总之，旱柳具有抗糖尿病作用和其他有益作用，可以改善糖尿病及其相关并发症。
