Medical Toxicology and Biochemistry Laboratory, Department of Zoology, Government College University, Lahore, 54000, Pakistan.
Inflammopharmacology. 2024 Oct;32(5):2695-2727. doi: 10.1007/s10787-024-01545-5. Epub 2024 Aug 13.
Numerous cellular, humoral, and molecular processes are involved in the intricate process of wound healing.
Numerous bioactive substances, such as ß-sitosterol, tannic acid, gallic acid, protocatechuic acid, quercetin, ellagic acid, and pyrogallol, along with their pharmacokinetics and bioavailability, have been reviewed. These phytochemicals work together to promote angiogenesis, granulation, collagen synthesis, oxidative balance, extracellular matrix (ECM) formation, cell migration, proliferation, differentiation, and re-epithelialization during wound healing.
To improve wound contraction, this review delves into how the application of each bioactive molecule mediates with the inflammatory, proliferative, and remodeling phases of wound healing to speed up the process. This review also reveals the underlying mechanisms of the phytochemicals against different stages of wound healing along with the differentiation of the in vitro evidence from the in vivo evidence There is growing interest in phytochemicals, or plant-derived compounds, due their potential health benefits. This calls for more scientific analysis and mechanistic research. The various pathways that these phytochemicals control/modulate to improve skin regeneration and wound healing are also briefly reviewed. The current review also elaborates the immunomodulatory modes of action of different phytochemicals during wound repair.
众多细胞、体液和分子过程参与到复杂的伤口愈合过程中。
许多生物活性物质，如β-谷甾醇、鞣酸、没食子酸、原儿茶酸、槲皮素、鞣花酸和焦性没食子酸，以及它们的药代动力学和生物利用度，已经被研究过。这些植物化学物质共同作用，促进血管生成、肉芽形成、胶原合成、氧化平衡、细胞外基质（ECM）形成、细胞迁移、增殖、分化和伤口愈合的再上皮化。
为了改善伤口收缩，本综述深入探讨了每种生物活性分子如何通过与炎症、增殖和重塑阶段的相互作用来加速伤口愈合过程。本综述还揭示了植物化学物质针对不同阶段的伤口愈合的潜在机制，以及体外证据与体内证据的区别。由于其潜在的健康益处，人们对植物化学物质或植物来源的化合物越来越感兴趣。这需要更多的科学分析和机制研究。这些植物化学物质控制/调节的改善皮肤再生和伤口愈合的各种途径也被简要综述。本综述还详细阐述了不同植物化学物质在伤口修复过程中的免疫调节作用模式。
