School of Pharmaceutical Science, Basic Medical Research Center of Tianjin, Tianjin Medical University, Tianjin, People's of Republic of China.
Nat Prod Res. 2010 Oct;24(17):1587-91. doi: 10.1080/14786410802696684.
A new labdanic norditerpene and six known labdanic diterpenes were isolated from the petroleum ether extract of the needles of Pinus sylvestris. By spectroscopic methods, the isolated compounds were determined as 15-norpinifolic acid (1), pinifolic acid (2), 4-eplimbricataloic acid (3), monomethyl pinifolate (4), 18α-acetoxylabd-8(17)-en-15-oic acid (5), 2-pentenoic acid (6) and 3β-hydroxy-8(17),E-13-labdadien-15-oic acid (7), respectively. Compound 1 showed significant anti-tumour activity.
从欧洲赤松针叶的石油醚提取物中分离得到一个新的拉巴烷型 Norditerpene 和六个已知的拉巴烷型二萜。通过光谱方法，分离得到的化合物分别确定为 15-降 pinifolic 酸（1）、pinifolic 酸（2）、4-eplimbricataloic 酸（3）、单甲基 pinifolate（4）、18α-acetoxylabd-8(17)-en-15-oic 酸（5）、2-戊烯酸（6）和 3β-羟基-8(17),E-13-labdadien-15-oic 酸（7）。化合物 1 表现出显著的抗肿瘤活性。
