辛拉迪萜烯 A-F，来自软珊瑚的新海松烷二萜。

Sinuladiterpenes A-F, new cembrane diterpenes from Sinularia flexibilis.

机构信息

Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.

出版信息

Chem Biodivers. 2009 Dec;6(12):2227-35. doi: 10.1002/cbdv.200800298.

DOI:10.1002/cbdv.200800298

PMID:20020460

Abstract

Chromatographic investigation of the octocoral Sinularia flexibilis afforded six new cembrane diterpenes, sinuladiterpenes A-F (1-6, resp.), in addition to four known cembranolides, 11-episinulariolide acetate, 11-dehydrosinulariolide, 11-episinulariolide, and sinulariolide. Their structures were elucidated by spectroscopic analysis, especially 2D-NMR and HR-ESI-MS. Compound 2 exhibited significant in vitro cytotoxic activity against human colon adenocarcinoma (WiDr) cell line.

摘要

色谱研究八角珊瑚提供了六个新的海鞘二萜，sinuladiterpenes A-F（1-6，分别），除了四个已知的cembranolides，11-episinulariolide 乙酸盐，11-脱水 sinulariolide，11-episinulariolide 和 sinulariolide。通过光谱分析，特别是二维 NMR 和 HR-ESI-MS，阐明了它们的结构。化合物 2 对人结肠腺癌细胞系（WiDr）具有显著的体外细胞毒性活性。