Department of Medical Research, Genetic Center, China Medical University Hospital, Taichung, Taiwan, Republic of China.
Ren Fail. 2010;32(10):1172-6. doi: 10.3109/0886022X.2010.516857.
Membranous glomerulonephritis (MGN) is viewed as an immune-mediated glomerular disease, with immunologic expression occurring in genetically susceptible persons. The cytokine interleukin-6 (IL-6) gene polymorphism is known to impair intracellular signaling pathways following adaptive immune response. Our study gauged the effects of IL-6 C-572G (rs1800796) single nucleotide polymorphism (SNP) on MGN among Taiwan's Han Chinese population, as analyzed in 265 controls and 106 MGN patients. Genotyping for IL-6 C-572G SNP was performed by restriction fragment length polymorphism assay. Data showed stark differences in genotype and allele frequency distributions at IL-6 C-572G SNP between MGN patients and controls (p = 1.6E-04 and 1.7E-04, respectively). People with C allele or with CC genotype at IL-6 C-572G SNP showed higher risk of MGN (odds ratio = 2.42 and 2.71, respectively; 95% confidence interval = 1.51-3.87 and 1.60-4.60, respectively). These point to IL-6 C-572G polymorphism as the underlying cause of MGN; polymorphism merits further investigation.
膜性肾小球肾炎（MGN）被视为一种免疫介导的肾小球疾病，在遗传易感人群中出现免疫表达。细胞因子白细胞介素-6（IL-6）基因多态性已知会破坏适应性免疫反应后的细胞内信号通路。我们的研究评估了 IL-6 C-572G（rs1800796）单核苷酸多态性（SNP）在台湾汉族人群中的 MGN 中的作用，在 265 名对照和 106 名 MGN 患者中进行了分析。通过限制性片段长度多态性分析检测 IL-6 C-572G SNP 的基因型。数据显示，在 MGN 患者和对照组中，IL-6 C-572G SNP 的基因型和等位基因频率分布存在明显差异（分别为 p = 1.6E-04 和 1.7E-04）。IL-6 C-572G SNP 处具有 C 等位基因或 CC 基因型的人患 MGN 的风险更高（比值比分别为 2.42 和 2.71；95%置信区间分别为 1.51-3.87 和 1.60-4.60）。这些结果表明 IL-6 C-572G 多态性是 MGN 的潜在原因；多态性值得进一步研究。
