Reproductive Medicine Center, Peking University Third Hospital, Beijing 100083, P.R. China.
Reprod Biol Endocrinol. 2010 Oct 18;8:122. doi: 10.1186/1477-7827-8-122.
This is a prospective study of 182 women (38 yrs or younger) undergoing IVF-ET. Endometrial thickness, echo pattern and blood flow on transvaginal ultrasonography were recorded eight hours prior to hCG administration. The patients were divided into three groups: A (n = 10) with undetectable endometrial blood flow; B (n = 82) with sub-endometrial blood flow; C (n = 90) with both endometrial and sub-endometrial blood flow. According to IVF-ET outcomes, all patients were re-divided into three groups: 1 non-pregnancy (n = 92); 2 intrauterine pregnancy with live fetus (n = 70); 3 others (n = 20 including biochemical pregnancy, embryonic diapause, ectopic pregnancy and miscarriage). Intrauterine pregnancy with live fetus in Group C (62.2%) was much higher than that in Group A and B (0% and 17.1%, p less than or equal to 0.001). The implantation rate (33.2%) was much higher than that in Group A and B (0% and 19.90%, p less than or equal to 0.001). The pulsatility index, resistance index, and S/D of endometrial spiral arteries were 0.1 +/- 0.2, 0.6 +/- 0.1 and 2.5 +/- 0.4 in Group 2, which were much lower than those in Group 1 and Group 3 (p1-2 less than 0.001, p2-3 less than 0.05). The patients with detectable endometrial blood flow had higher clinical pregnancy rates and implantation rates.
这是一项对 182 名接受 IVF-ET 的女性（38 岁或以下）进行的前瞻性研究。在 hCG 给药前 8 小时，通过经阴道超声记录子宫内膜厚度、回声模式和血流。患者分为三组：A 组（n = 10）子宫内膜血流不可检测；B 组（n = 82）子宫内膜下血流；C 组（n = 90）子宫内膜和子宫内膜下血流均有。根据 IVF-ET 结果，所有患者重新分为三组：1 非妊娠（n = 92）；2 宫内妊娠伴活胎（n = 70）；3 其他（n = 20，包括生化妊娠、胚胎休眠、异位妊娠和流产）。C 组（62.2%）宫内妊娠伴活胎的比例明显高于 A 组和 B 组（0%和 17.1%，p 小于或等于 0.001）。着床率（33.2%）明显高于 A 组和 B 组（0%和 19.90%，p 小于或等于 0.001）。2 组子宫内膜螺旋动脉搏动指数、阻力指数和 S/D 分别为 0.1 +/- 0.2、0.6 +/- 0.1 和 2.5 +/- 0.4，明显低于 1 组和 3 组（p1-2 小于 0.001，p2-3 小于 0.05）。可检测到子宫内膜血流的患者具有更高的临床妊娠率和着床率。
