Faculty of Pharmaceutical Sciences, Federal University of Alfenas-MG, 37130-000 Alfenas, Brazil.
J Ethnopharmacol. 2011 Jan 27;133(2):467-73. doi: 10.1016/j.jep.2010.09.036. Epub 2010 Oct 16.
In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain. Nevertheless, scientific information regarding Garcinia brasiliensis is limited; there are no reports related to its possible anti-inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Garcinia brasiliensis.
Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the anti-inflammatory activity of Garcinia brasiliensis ethanolic extract (GbEE) in rats. Formalin and acetic acid-induced writhing tests were used to investigate the antinociceptive activity in mice.
GbEE at test doses of 30-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan, inhibited leukocyte recruitment into the peritoneal cavity, and in the model of chronic inflammation using the cotton pellet-induced fibrovascular tissue growth in rats, the GbEE significantly inhibited the formation of granulomatous tissue. The extracts at test doses of 30-300 mg/kg, p.o., clearly demonstrated antinociceptive activity, except for the first phase of the formalin test.
GbEE markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports previous claims of the traditional use of species of the Garcinia genus for inflammation and pain.
在巴西民间医学中，使用藤黄属植物的叶子来治疗肿瘤、尿路感染和关节炎以及缓解疼痛。然而，关于藤黄属植物的科学信息有限；没有关于其可能的抗炎和镇痛作用的报道。本研究采用体内炎症和疼痛模型来评估藤黄属植物传统用途的科学依据。
使用角叉菜胶诱导的爪肿胀、皮下植入棉塞引起的腹膜炎和纤维血管组织生长来研究藤黄属植物乙醇提取物（GbEE）在大鼠中的抗炎活性。甲醛和乙酸诱导的扭体试验用于研究小鼠的镇痛活性。
GbEE 在测试剂量为 30-300 mg/kg 口服时，通过减少角叉菜胶诱导的爪肿胀、抑制白细胞募集到腹腔以及在使用棉塞诱导的纤维血管组织生长的慢性炎症模型中，明显表现出抗炎作用。提取物在测试剂量为 30-300 mg/kg 口服时，明显表现出镇痛活性，除了甲醛试验的第一阶段。
GbEE 在大鼠中表现出明显的抗炎作用，在小鼠中表现出镇痛活性，这支持了先前关于使用藤黄属植物治疗炎症和疼痛的传统用途的说法。
