帕金森病发病途径的遗传学分析。
Genetic analysis of pathways to Parkinson disease.
机构信息
Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
出版信息
Neuron. 2010 Oct 21;68(2):201-6. doi: 10.1016/j.neuron.2010.10.014.
Abstract
In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now have genetically identified on the order of half our risk for developing the disease.
摘要
在这篇综述中，我概述了我们是否应该将帕金森病视为一种或多种实体的论点，并在该背景下讨论孟德尔和全基因组关联分析的遗传发现。我讨论了疾病传播的证明对我们分析疾病的遗传和流行病学风险因素意味着什么，并概述了一个令人惊讶的事实，即我们现在已经通过基因确定了大约一半的患病风险。
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