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波兰出现同时产生 KPC-2 和 16S rRNA 甲基酶 ArmA 的肺炎克雷伯菌。

Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland.

机构信息

Department of Bacteriology, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.

出版信息

Antimicrob Agents Chemother. 2011 Jan;55(1):443-6. doi: 10.1128/AAC.00386-10. Epub 2010 Oct 18.

DOI:10.1128/AAC.00386-10
PMID:20956599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3019640/
Abstract

A Klebsiella pneumoniae epidemic strain that coproduced carbapenemase KPC-2 (K. pneumoniae carbapenemase 2) and 16S rRNA methylase ArmA has emerged in Poland. Four nonduplicate isolates from patients in a hospital in Warsaw, Poland, were found to carry the bla(KPC-2) and armA genes on ca. 50-kb and 90-kb plasmids, respectively. Tn4401 with a 100-bp deletion in the variable region was detected in all the isolates. XbaI pulsed-field gel electrophoresis (PFGE) revealed 93.2% similarity of the isolates. All the isolates were resistant to carbapenems and 4,6-disubstituted 2-deoxystreptamines.

摘要

波兰出现了一株同时产生碳青霉烯酶 KPC-2（肺炎克雷伯菌碳青霉烯酶 2）和 16S rRNA 甲基酶 ArmA 的肺炎克雷伯氏菌流行株。从波兰华沙一家医院的 4 名患者的 4 个非重复分离株中发现，bla(KPC-2)和 armA 基因分别位于约 50kb 和 90kb 的质粒上。在所有分离株中均检测到了带有 100bp 缺失的 Tn4401。XbaI 脉冲场凝胶电泳（PFGE）显示分离株的相似度为 93.2%。所有分离株均对碳青霉烯类药物和 4,6-二取代 2-去氧链霉胺具有抗性。

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Carriage of genes for various extended-spectrum beta-lactamases: a novel resistance strategy of Klebsiella pneumoniae in Poland.携带各种扩展谱β-内酰胺酶的基因：波兰肺炎克雷伯菌的一种新型耐药策略。
Int J Antimicrob Agents. 2010 Apr;35(4):392-5. doi: 10.1016/j.ijantimicag.2009.12.010.
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