波兰出现同时产生 KPC-2 和 16S rRNA 甲基酶 ArmA 的肺炎克雷伯菌。
Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland.
机构信息
Department of Bacteriology, National Institute of Public Health-National Institute of Hygiene, Warsaw, Poland.
出版信息
Antimicrob Agents Chemother. 2011 Jan;55(1):443-6. doi: 10.1128/AAC.00386-10. Epub 2010 Oct 18.
Abstract
A Klebsiella pneumoniae epidemic strain that coproduced carbapenemase KPC-2 (K. pneumoniae carbapenemase 2) and 16S rRNA methylase ArmA has emerged in Poland. Four nonduplicate isolates from patients in a hospital in Warsaw, Poland, were found to carry the bla(KPC-2) and armA genes on ca. 50-kb and 90-kb plasmids, respectively. Tn4401 with a 100-bp deletion in the variable region was detected in all the isolates. XbaI pulsed-field gel electrophoresis (PFGE) revealed 93.2% similarity of the isolates. All the isolates were resistant to carbapenems and 4,6-disubstituted 2-deoxystreptamines.
摘要
波兰出现了一株同时产生碳青霉烯酶 KPC-2（肺炎克雷伯菌碳青霉烯酶 2）和 16S rRNA 甲基酶 ArmA 的肺炎克雷伯氏菌流行株。从波兰华沙一家医院的 4 名患者的 4 个非重复分离株中发现，bla(KPC-2)和 armA 基因分别位于约 50kb 和 90kb 的质粒上。在所有分离株中均检测到了带有 100bp 缺失的 Tn4401。XbaI 脉冲场凝胶电泳（PFGE）显示分离株的相似度为 93.2%。所有分离株均对碳青霉烯类药物和 4,6-二取代 2-去氧链霉胺具有抗性。
相似文献
1
Emergence of Klebsiella pneumoniae coproducing KPC-2 and 16S rRNA methylase ArmA in Poland.波兰出现同时产生 KPC-2 和 16S rRNA 甲基酶 ArmA 的肺炎克雷伯菌。
Antimicrob Agents Chemother. 2011 Jan;55(1):443-6. doi: 10.1128/AAC.00386-10. Epub 2010 Oct 18.
2
Plasmid-borne 16S rRNA methylase ArmA in aminoglycoside-resistant Klebsiella pneumoniae in Poland.波兰耐氨基糖苷类药物肺炎克雷伯菌中质粒携带的 16S rRNA 甲基酶 ArmA。
J Med Microbiol. 2011 Sep;60(Pt 9):1306-1311. doi: 10.1099/jmm.0.024026-0. Epub 2011 Jan 20.
3
Diverse prevalence of 16S rRNA methylase genes armA and rmtB amongst clinical multidrug-resistant Escherichia coli and Klebsiella pneumoniae isolates.临床多重耐药的大肠埃希菌和肺炎克雷伯菌分离株中 16S rRNA 甲基酶基因 armA 和 rmtB 的不同流行率。
Int J Antimicrob Agents. 2011 Oct;38(4):348-51. doi: 10.1016/j.ijantimicag.2011.04.021. Epub 2011 Jul 2.
4
High Prevalence of 16s rRNA Methylase Genes Among Carbapenem-Resistant Hypervirulent Isolates in a Chinese Tertiary Hospital.中国一家三甲医院中高毒力碳青霉烯类耐药的 16s rRNA 甲基酶基因的高流行率。
Microb Drug Resist. 2021 Jan;27(1):44-52. doi: 10.1089/mdr.2019.0482. Epub 2020 May 19.
5
Prevalence of β-lactamases and 16S rRNA methylase genes amongst clinical Klebsiella pneumoniae isolates carrying plasmid-mediated quinolone resistance determinants.产质粒介导喹诺酮类耐药决定因子的临床肺炎克雷伯菌分离株中β-内酰胺酶和 16S rRNA 甲基化酶基因的流行率。
Int J Antimicrob Agents. 2011 Apr;37(4):352-5. doi: 10.1016/j.ijantimicag.2010.12.018. Epub 2011 Mar 3.
6
Molecular characterization of the bla(KPC-2) gene in clinical isolates of carbapenem-resistant Klebsiella pneumoniae from the pediatric wards of a Chinese hospital.临床分离碳青霉烯类耐药肺炎克雷伯菌中 bla(KPC-2) 基因的分子特征：中国某医院儿科病房的研究。
Can J Microbiol. 2012 Oct;58(10):1167-73. doi: 10.1139/w2012-094. Epub 2012 Sep 14.
7
Plasmid-mediated 16S rRNA methylases conferring high-level aminoglycoside resistance in Escherichia coli and Klebsiella pneumoniae isolates from two Taiwanese hospitals.在来自台湾两家医院的大肠杆菌和肺炎克雷伯菌分离株中，质粒介导的16S rRNA甲基化酶赋予高水平氨基糖苷类耐药性
J Antimicrob Chemother. 2004 Dec;54(6):1007-12. doi: 10.1093/jac/dkh455. Epub 2004 Oct 14.
8
Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital.从纽约市一家医院分离出的克雷伯氏菌菌株质粒上 blaKPC 碳青霉烯酶基因周围转座酶区域的基因组织。
Antimicrob Agents Chemother. 2009 May;53(5):1998-2004. doi: 10.1128/AAC.01355-08. Epub 2009 Mar 2.
9
Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden.挪威和瑞典出现序列型258的克隆相关肺炎克雷伯菌分离株，这些分离株产生质粒介导的KPC碳青霉烯酶。
J Antimicrob Chemother. 2009 Apr;63(4):654-8. doi: 10.1093/jac/dkp018. Epub 2009 Feb 13.
10
Molecular epidemiology of carbapenem resistant Enterobacteriaceae in Valle d'Aosta region, Italy, shows the emergence of KPC-2 producing Klebsiella pneumoniae clonal complex 101 (ST101 and ST1789).意大利瓦莱达奥斯塔地区耐碳青霉烯类肠杆菌科的分子流行病学研究显示，产 KPC-2 的肺炎克雷伯菌克隆复合体 101（ST101 和 ST1789）的出现。
BMC Microbiol. 2015 Nov 9;15(1):260. doi: 10.1186/s12866-015-0597-z.
引用本文的文献
1
Clonal Dissemination of KPC-2, VIM-1, OXA-48-Producing ST147 in Katowice, Poland.波兰卡托维兹地区产 KPC-2、VIM-1、OXA-48 的 ST147 克隆传播。
Pol J Microbiol. 2021 Mar;70(1):107-116. doi: 10.33073/pjm-2021-010. Epub 2021 Mar 19.
2
fosA3 overexpression with transporter mutations mediates high-level of fosfomycin resistance and silence of fosA3 in fosfomycin-susceptible Klebsiella pneumoniae producing carbapenemase clinical isolates.携带转运基因突变的 fosA3 过度表达导致高产水平的磷霉素耐药性，并使产碳青霉烯酶的敏感型肺炎克雷伯菌临床分离株中的 fosA3 沉默。
PLoS One. 2020 Aug 28;15(8):e0237474. doi: 10.1371/journal.pone.0237474. eCollection 2020.
3
Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation.氨基糖苷类药物的复兴：对一类正在经历复兴的具有历史重要性的抗菌药物的综述
EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018.
4
RAPD PCR Profile, Antibiotic Resistance, Prevalence of Gene, and Detection of KPC Enzyme in Isolates.分离株的随机扩增多态性PCR图谱、抗生素耐药性、基因流行率及KPC酶检测
Can J Infect Dis Med Microbiol. 2018 Feb 4;2018:6183162. doi: 10.1155/2018/6183162. eCollection 2018.
5
Successful ceftazidime-avibactam treatment of MDR-KPC-positive Klebsiella pneumoniae infection in a patient with traumatic brain injury: A case report.头孢他啶-阿维巴坦成功治疗创伤性脑损伤患者的多重耐药KPC阳性肺炎克雷伯菌感染：一例报告
Medicine (Baltimore). 2017 Aug;96(31):e7664. doi: 10.1097/MD.0000000000007664.
6
Clonal Spread of 16S rRNA Methyltransferase-Producing ST37 with High Prevalence of ESBLs from Companion Animals in China.中国产超广谱β-内酰胺酶（ESBLs）的ST37 16S rRNA甲基转移酶产生菌在伴侣动物中的克隆传播
Front Microbiol. 2017 Mar 29;8:529. doi: 10.3389/fmicb.2017.00529. eCollection 2017.
7
An Outbreak of Infections Caused by a Klebsiella pneumoniae ST11 Clone Coproducing Klebsiella pneumoniae Carbapenemase-2 and RmtB in a Chinese Teaching Hospital.中国一家教学医院中由产肺炎克雷伯菌碳青霉烯酶-2和RmtB的肺炎克雷伯菌ST11克隆株引起的感染暴发
Chin Med J (Engl). 2016 Sep 5;129(17):2033-9. doi: 10.4103/0366-6999.189049.
8
NDM-1 Metallo-β-Lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal.在尼泊尔发现产 NDM-1 金属β-内酰胺酶和 ArmA 16S rRNA 甲基酶的 Providencia rettgeri 临床分离株。
BMC Infect Dis. 2014 Feb 3;14:56. doi: 10.1186/1471-2334-14-56.
9
Coproduction of 16S rRNA methyltransferase RmtD or RmtG with KPC-2 and CTX-M group extended-spectrum β-lactamases in Klebsiella pneumoniae.肺炎克雷伯菌中 16S rRNA 甲基转移酶 RmtD 或 RmtG 与 KPC-2 和 CTX-M 组超广谱β-内酰胺酶的共表达。
Antimicrob Agents Chemother. 2013 May;57(5):2397-400. doi: 10.1128/AAC.02108-12. Epub 2013 Mar 4.
10
Epidemic of Klebsiella pneumoniae ST11 clone coproducing KPC-2 and 16S rRNA methylase RmtB in a Chinese University Hospital.中国某大学医院中产 KPC-2 和 16S rRNA 甲基酶 RmtB 的肺炎克雷伯菌 ST11 克隆的流行。
BMC Infect Dis. 2012 Dec 23;12:373. doi: 10.1186/1471-2334-12-373.
本文引用的文献
1
Complete nucleotide sequence of Klebsiella pneumoniae multidrug resistance plasmid pKP048, carrying blaKPC-2, blaDHA-1, qnrB4, and armA.肺炎克雷伯菌多药耐药质粒 pKP048 的完整核苷酸序列，携带 blaKPC-2、blaDHA-1、qnrB4 和 armA。
Antimicrob Agents Chemother. 2010 Sep;54(9):3967-9. doi: 10.1128/AAC.00137-10. Epub 2010 Jun 14.
2
Carriage of genes for various extended-spectrum beta-lactamases: a novel resistance strategy of Klebsiella pneumoniae in Poland.携带各种扩展谱β-内酰胺酶的基因：波兰肺炎克雷伯菌的一种新型耐药策略。
Int J Antimicrob Agents. 2010 Apr;35(4):392-5. doi: 10.1016/j.ijantimicag.2009.12.010.
3
Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China.中国产碳青霉烯类耐药阴沟肠杆菌中质粒介导的碳青霉烯水解酶 KPC-2 和 ArmA 16S rRNA 甲基酶导致高水平氨基糖苷类耐药性。
Diagn Microbiol Infect Dis. 2010 Mar;66(3):326-8. doi: 10.1016/j.diagmicrobio.2009.10.003. Epub 2009 Nov 10.
4
Interspecies spread of Klebsiella pneumoniae carbapenemase gene in a single patient.在单个患者中肠杆菌科碳青霉烯酶基因的种间传播。
Clin Infect Dis. 2009 Dec 1;49(11):1736-8. doi: 10.1086/648077.
5
Emergence of Klebsiella pneumoniae ST258 with KPC-2 in Poland.波兰出现携带KPC-2的肺炎克雷伯菌ST258。
Antimicrob Agents Chemother. 2009 Oct;53(10):4565-7. doi: 10.1128/AAC.00436-09. Epub 2009 Jul 20.
6
Identification of the aminoglycoside resistance determinants armA and rmtC among non-Typhi Salmonella isolates from humans in the United States.在美国从人类分离出的非伤寒沙门氏菌菌株中鉴定氨基糖苷类耐药决定簇armA和rmtC 。
Antimicrob Agents Chemother. 2009 Oct;53(10):4563-4. doi: 10.1128/AAC.00656-09. Epub 2009 Jul 13.
7
Clonal spread of KPC-2 carbapenemase-producing Klebsiella pneumoniae strains in Greece.产KPC-2碳青霉烯酶肺炎克雷伯菌菌株在希腊的克隆传播。
J Antimicrob Chemother. 2009 Aug;64(2):348-52. doi: 10.1093/jac/dkp207. Epub 2009 Jun 13.
8
Molecular epidemiology of KPC-producing Klebsiella pneumoniae isolates in the United States: clonal expansion of multilocus sequence type 258.美国产KPC肺炎克雷伯菌分离株的分子流行病学：多位点序列类型258的克隆扩增
Antimicrob Agents Chemother. 2009 Aug;53(8):3365-70. doi: 10.1128/AAC.00126-09. Epub 2009 Jun 8.
9
Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital.从纽约市一家医院分离出的克雷伯氏菌菌株质粒上 blaKPC 碳青霉烯酶基因周围转座酶区域的基因组织。
Antimicrob Agents Chemother. 2009 May;53(5):1998-2004. doi: 10.1128/AAC.01355-08. Epub 2009 Mar 2.
10
Emergence of clonally related Klebsiella pneumoniae isolates of sequence type 258 producing plasmid-mediated KPC carbapenemase in Norway and Sweden.挪威和瑞典出现序列型258的克隆相关肺炎克雷伯菌分离株，这些分离株产生质粒介导的KPC碳青霉烯酶。
J Antimicrob Chemother. 2009 Apr;63(4):654-8. doi: 10.1093/jac/dkp018. Epub 2009 Feb 13.
Zotero 插件