通过转移氢化对反式-β-羟基-α-酰胺酯的对映选择性合成。
Enantioselective synthesis of anti-β-hydroxy-α-amido esters via transfer hydrogenation.
机构信息
Organic Chemistry, KTH Chemical Science and Engineering, Royal Institute of Technology, 100 44 Stockholm, Sweden.
出版信息
Org Lett. 2010 Nov 19;12(22):5274-7. doi: 10.1021/ol102323k. Epub 2010 Oct 21.
PMID:20964324
Abstract
The asymmetric transfer hydrogenation of α-amido-β-keto esters to provide the corresponding anti-β-hydroxy-α-amido esters in good to excellent yields, diastereoselectivity, and enantioselectivity is reported. The procedure is operationally simple, and delicate handling of the catalyst is not necessary.
摘要
报道了一种通过不对称转移氢化将α-酰胺基-β-酮酯转化为相应的反式-β-羟基-α-酰胺酯的方法，该方法具有良好到优秀的产率、非对映选择性和对映选择性。该过程操作简单，不需要对催化剂进行精细处理。
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