Bergère A, Lortholary A, Cornu P, Richard C, Bertrand G, Perrin A, Delpon A, Bernaille C
Service de Médecine Interne, Centre Hospitalier, Sable S Sarthe.
Rev Med Interne. 1990 Jul-Aug;11(4):316-8. doi: 10.1016/s0248-8663(05)80865-3.
Cutaneous neuroendocrine carcinoma (CNEC) is a rare tumour. We report the case of a 75-year old woman affected with a rapidly progressive CNEC of the right cheek which kept recurring despite surgical excision followed by radiotherapy. The clinical features of CNEC are not specific. The tumour is located in the dermis, and the tumoral cells (Merkel cells) have a monotonous appearance. Gould's classification of these carcinomas into three types has a prognostic value. Immunohistochemistry is a mandatory complement to light microscope examination. It is very difficult to distinguish between CNEC and metastasis from a visceral small cell carcinoma. Treatment consists of surgery combined with radiotherapy. Chemotherapy was very successful in our patient and should be considered in other cases.
皮肤神经内分泌癌（CNEC）是一种罕见的肿瘤。我们报告了一例75岁女性患者，其右脸颊患有快速进展的CNEC，尽管手术切除后进行了放疗，但仍不断复发。CNEC的临床特征不具有特异性。肿瘤位于真皮层，肿瘤细胞（默克尔细胞）外观单一。古尔德将这些癌分为三种类型的分类方法具有预后价值。免疫组织化学是光学显微镜检查必不可少的补充。很难区分CNEC和内脏小细胞癌的转移。治疗包括手术联合放疗。化疗在我们的患者中非常成功，其他病例也应考虑采用化疗。
