British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, Scotland, UK.
Pharmacol Ther. 2011 Jan;129(1):29-49. doi: 10.1016/j.pharmthera.2010.10.004. Epub 2010 Oct 20.
Several types of stem and progenitor cells are currently under investigation for their potential to accomplish vascular regeneration. This review focuses on embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). We will discuss the technologies allowing for their derivation, culture expansion and maintenance in a pluripotent status. Moreover, both ESCs and iPSCs can be differentiated in endothelial cells (ECs) and mural cell, including vascular smooth muscle cells (VSMCs). Here, we will describe the involvements of growth factors (vascular endothelial growth factors-VEGFs-, platet-derived growth factors-PDGFs-), Wnt and Notch signal pathways, reactive oxygen species (ROS), histone deacetylases (HDACs), and microRNAs (miRNAs) in vascular cell differentiation from pluripotent stem cells. We will additionally describe the therapeutic potential of stem cells for vascular medicine.
目前，多种类型的干细胞和祖细胞正在被研究用于实现血管再生。本篇综述聚焦于胚胎干细胞（ESCs）和诱导多能干细胞（iPSCs）。我们将讨论使它们能够衍生、培养扩增和维持多能状态的技术。此外，ESCs 和 iPSCs 都可以分化为内皮细胞（ECs）和壁细胞，包括血管平滑肌细胞（VSMCs）。在这里，我们将描述生长因子（血管内皮生长因子-VEGFs-，血小板衍生生长因子-PDGFs-）、Wnt 和 Notch 信号通路、活性氧（ROS）、组蛋白去乙酰化酶（HDACs）和 microRNAs（miRNAs）在多能干细胞向血管细胞分化中的作用。我们还将描述干细胞在血管医学中的治疗潜力。
