Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China.
PLoS One. 2010 Oct 13;5(10):e13316. doi: 10.1371/journal.pone.0013316.
Few data have been published on the associations of ferritin with trunk and leg fat depots. We aimed to investigate these associations in a Chinese population.
Trunk fat mass and leg fat mass were determined in a cross-sectional sample of 1,150 Chinese (479 men and 671 women) aged 50-70 years by dual-energy X-ray absorptiometry scan. Fasting plasma ferritin was measured.
Plasma ferritin was positively correlated with waist circumference, waist-to-hip ratio, total body fat and trunk fat mass, but inversely correlated with leg fat mass in men (r = 0.16, 0.26, 0.19, 0.22 and -0.12, respectively, all P<0.05) and women (r = 0.16, 0.16, 0.08, 0.17 and -0.12, respectively, all P<0.05). Multivariate regression analysis showed that ferritin levels increased with larger trunk fat mass (β = 0.33 ± 0.08 for men and β = 0.21 ± 0.05 for women, both P<0.001) while decreased with larger leg fat mass (β = -0.12 ± 0.09, P = 0.15 for men; and β = -0.14 ± 0.05, P = 0.005 for women). Moreover, plasma ferritin levels decreased with increasing tertile of leg fat mass among each tertile of trunk fat mass.
This is the first study to report the opposite associations of trunk and leg fat depots with plasma ferritin levels.
关于铁蛋白与躯干和腿部脂肪沉积的关系，仅有少量数据发表。我们旨在研究中国人群中的这些关联。
通过双能 X 射线吸收法扫描，对 1150 名年龄在 50-70 岁的中国人（479 名男性和 671 名女性）进行了横断面样本的躯干脂肪量和腿部脂肪量的测定。测量了空腹血浆铁蛋白。
男性（r=0.16、0.26、0.19、0.22 和-0.12，均 P<0.05）和女性（r=0.16、0.16、0.08、0.17 和-0.12，均 P<0.05）中，血浆铁蛋白与腰围、腰臀比、全身脂肪和躯干脂肪量呈正相关，与腿部脂肪量呈负相关。多元回归分析显示，铁蛋白水平随着躯干脂肪量的增加而升高（男性β=0.33±0.08，P<0.001；女性β=0.21±0.05，P<0.001），随着腿部脂肪量的增加而降低（男性β=-0.12±0.09，P=0.15；女性β=-0.14±0.05，P=0.005）。此外，在每个躯干脂肪量三分位中，随着腿部脂肪量三分位的增加，血浆铁蛋白水平呈下降趋势。
这是第一项报告躯干和腿部脂肪沉积与血浆铁蛋白水平呈相反关联的研究。
