Abioye A A
Afr J Med Med Sci. 1977 Sep;6(3):119-23.
By means of chromatography different fractions of antigens from Entamoeba histolytica (Ibadan Strains) have been separated. All the different fractions have been tested for antigenic reactivity using agar gel diffusion technique. The intact antigen, as well as, the three antigenically reactive fractions were found to have ultra-violet absorption spectra in the region 258 and 278 millimicron. By virtue of this physico-chemical property amoebic extract(s) was found to simulate a mononucleotide Deoxy-5-methyl-cytidilic-acid. Such a unique structure of the extracts was used to suggest a mechanism for the possible low antigenicity of the organism based on its inability to induce a protective antibody response in human amoebiasis.
通过色谱法，已分离出溶组织内阿米巴（伊巴丹菌株）抗原的不同组分。使用琼脂凝胶扩散技术对所有不同组分进行了抗原反应性测试。发现完整抗原以及三种具有抗原反应性的组分在258和278毫微米区域具有紫外吸收光谱。凭借这种物理化学性质，发现阿米巴提取物模拟单核苷酸脱氧-5-甲基胞苷酸。提取物的这种独特结构被用来提出一种机制，解释该生物体在人类阿米巴病中可能因无法诱导保护性抗体反应而具有低抗原性的原因。
