Institute of Immunology, National Health Laboratory and Centre de Recherche Public-Santé, Luxembourg.
Clin Microbiol Infect. 2011 Aug;17(8):1173-6. doi: 10.1111/j.1469-0691.2010.03407.x. Epub 2011 Apr 12.
The genetic diversity of norovirus strains obtained from gastroenteritis outbreaks, sporadic case surveillance and wastewater plants was compared in Luxembourg from October 2008 until June 2009. Except for GI.6 and GIV.1 strains detected exclusively in wastewater, all other genotypes were also found in human samples. Of the nine NoV genotypes detected, only three (GII.4, GIIb/II.3 and GIIc/II.12) were associated with institutional outbreaks. The majority of sequences from all sources belonged to genotype GII.4, including two potentially new sub-variants. Strains collected in the context of outbreaks may significantly under-represent the overall genetic diversity of NoVs circulating in a country.
2008 年 10 月至 2009 年 6 月，卢森堡对从肠胃炎暴发、散发病例监测和废水处理厂中获得的诺如病毒株的遗传多样性进行了比较。除了仅在废水中检测到的 GI.6 和 GIV.1 株外，所有其他基因型也在人类样本中被发现。在所检测到的 9 种诺如病毒基因型中，只有 3 种（GII.4、GIIb/II.3 和 GIIc/II.12）与机构暴发有关。所有来源的大多数序列都属于基因型 GII.4，其中包括两种可能的新亚型。在暴发情况下收集的菌株可能显著低估了在一个国家中传播的诺如病毒的总体遗传多样性。
