FAME Laboratory, Institute of Human Performance and Rehabilitation, Centre for Research and Technology Thessaly, Trikala, Greece.
Ageing Res Rev. 2011 Jan;10(1):153-62. doi: 10.1016/j.arr.2010.10.001. Epub 2010 Oct 20.
Caloric restriction (CR) causes a reduction in body temperature (T(b)) which is suggested to contribute to changes that increase lifespan. Moreover, low T(b) has been shown to improve health and longevity independent of CR. In this review we examine the connections between CR, T(b) and mechanisms that influence longevity and ageing. Recent findings regarding the overlapping mechanisms of CR and T(b) that benefit longevity are discussed, including changes in body composition, hormone regulation, and gene expression, as well as reductions in low-level inflammation and reactive oxygen species-induced molecular damage. This information is summarized in a model describing how CR and low T(b), both synergistically and independently, increase lifespan. Moreover, the nascent notion that the rate of ageing may be pre-programmed in response to environmental influences at critical periods of early development is also considered. Based on current evidence, it is concluded that low T(b) plays an integral role in mediating the effects of CR on health and longevity, and that low T(b) may exert independent biological changes that increase lifespan. Our understanding of the overlap between CR- and T(b)-mediated longevity remains incomplete and should be explored in future research.
热量限制（CR）会导致体温（T(b)）降低，这被认为有助于延长寿命的变化。此外，低 T(b) 已被证明可以改善健康和延长寿命，而与 CR 无关。在这篇综述中，我们研究了 CR、T(b)与影响寿命和衰老的机制之间的联系。讨论了最近关于 CR 和 T(b) 的重叠机制有益于长寿的发现，包括身体成分、激素调节和基因表达的变化，以及低水平炎症和活性氧诱导的分子损伤的减少。这些信息总结在一个描述 CR 和低 T(b) 如何协同和独立地增加寿命的模型中。此外，还考虑了一种新的观点，即衰老的速度可能是对早期发育关键时期环境影响的预先编程。基于目前的证据，可以得出结论，低 T(b) 在介导 CR 对健康和长寿的影响方面起着重要作用，低 T(b) 可能会产生独立的生物学变化，从而延长寿命。我们对 CR 和 T(b) 介导的长寿之间的重叠的理解仍然不完整，应该在未来的研究中进行探索。
