Department of Microbiology & Immunology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, United States.
Curr Opin Immunol. 2011 Feb;23(1):81-7. doi: 10.1016/j.coi.2010.09.007. Epub 2010 Oct 21.
The major histocompatibility complex class II (MHC-II) genes are regulated at the level of transcription. Recent studies have shown that chromatin modification is critical for efficient transcription of these genes, and a number of chromatin modifying complexes recruited to MHC-II genes have been described. The MHC-II genes are segregated from each other by a series of chromatin elements, termed MHC-II insulators. Interactions between MHC-insulators and the promoters of MHC-II genes are mediated by the insulator factor CCCTC-binding factor and are critical for efficient expression. This regulatory mechanism provides a novel view of how the entire MHC-II locus is assembled architecturally and can be coordinately controlled.
主要组织相容性复合体 II 类 (MHC-II) 基因在转录水平上受到调控。最近的研究表明，染色质修饰对于这些基因的有效转录至关重要，并且已经描述了许多募集到 MHC-II 基因的染色质修饰复合物。MHC-II 基因通过一系列称为 MHC-II 绝缘子的染色质元件彼此隔离。MHC-II 绝缘子与 MHC-II 基因的启动子之间的相互作用由绝缘子因子 CCCTC 结合因子介导，对于有效表达至关重要。这种调节机制为整个 MHC-II 基因座如何在结构上进行组装并进行协调控制提供了新的视角。
