VI 型分泌系统调控：串扰与细胞内通讯。
Type VI secretion regulation: crosstalk and intracellular communication.
机构信息
Department of Biology, Faculty of Natural and Applied Sciences, Trinity Western University, 7600 Glover Road, Langley, BC V2Y 1Y1, Canada.
出版信息
Curr Opin Microbiol. 2011 Feb;14(1):9-15. doi: 10.1016/j.mib.2010.09.017.
Pathogens use type VI secretion systems (T6SSs) to transport proteins into the environment or host cells in response to external stimuli. T6SSs are tightly regulated together with other virulence determinants such as type III secretion systems, quorum sensing (QS), and flagella synthesis. Five pathogens (Salmonella enterica, Edwardsiella tarda, Aeromonas hydrophila, Vibrio cholerae, and Pseudomonas aeruginosa) are examined for crosstalk proteins (global regulators) that connect T6SSs to other virulence determinants. Common transcriptional regulators (TRs) include two component systems (i.e. PhoPQ), σ(54) and σ(54)-dependent TRs (i.e. VasH), and QS regulators. Greater understanding of this integral communication network will define what is essential for bacterial pathogenesis.
病原体利用六型分泌系统（T6SS）在受到外部刺激时将蛋白质输送到环境或宿主细胞中。T6SS 与其他毒力决定因素（如 III 型分泌系统、群体感应（QS）和鞭毛合成）一起受到严格调控。对五种病原体（沙门氏菌、迟缓爱德华菌、嗜水气单胞菌、霍乱弧菌和铜绿假单胞菌）进行了交叉对话蛋白（全局调节剂）的检测，这些蛋白将 T6SS 与其他毒力决定因素联系起来。常见的转录调节剂（TRs）包括双组分系统（即 PhoPQ）、σ（54）和 σ（54）依赖性 TRs（即 VasH）和 QS 调节剂。对这个完整的通讯网络的更深入了解将确定细菌发病机制的关键因素。
Zotero 插件