Institut Pasteur de Lille, Lactic Acid Bacteria & Mucosal Immunity, Center for Infection and Immunity of Lille, 1, Rue du Pr Calmette, BP 245, F-59019 Lille, France.
Appl Environ Microbiol. 2010 Dec;76(24):8259-64. doi: 10.1128/AEM.01976-10. Epub 2010 Oct 22.
Immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (PBMCs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (IL-10). Two selected strains of Propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria.
对 10 种乳制品丙酸杆菌的免疫调节特性进行分析,发现其对人外周血单核细胞(PBMC)中抗炎细胞因子白细胞介素 10(IL-10)的诱导具有高度的菌株依赖性。两种筛选出的弗氏丙酸杆菌(Propionibacterium freudenreichii)菌株对两种结肠炎模型的小鼠具有保护作用,这表明这些干酪发酵剂细菌的免疫选择标准预测了其具有益生菌潜力。