谷氨酰胺对小鼠脾脏白细胞对T细胞和B细胞有丝分裂原反应的影响。
The effect of glutamine on murine splenic leukocyte responses to T and B cell mitogens.
作者信息
Griffiths M, Keast D
机构信息
University Department of Microbiology, Queen Elizabeth II Medical Centre, Nedlands, Western Australia.
出版信息
Immunol Cell Biol. 1990 Dec;68 ( Pt 6):405-8. doi: 10.1038/icb.1990.54.
Murine splenic leukocytes cannot be stimulated to synthesize [3H]-DNA by various concentrations of either the T cell mitogens, Concanavalin-A (Con-A) or phytohaemagglutinin (PHA) or the B cell mitogen, lipopolysaccharide (LPS), unless glutamine is present in the culture medium. The optimum concentration of the T cell mitogens (Con-A, PHA) remained constant for all levels of glutamine while that of the B cell mitogen (LPS) increased as the concentration of glutamine in the medium increased.
除非培养基中存在谷氨酰胺，否则不同浓度的T细胞促有丝分裂原刀豆球蛋白A（Con-A）或植物血凝素（PHA）以及B细胞促有丝分裂原脂多糖（LPS）都无法刺激小鼠脾脏白细胞合成[3H]-DNA。对于所有谷氨酰胺水平，T细胞促有丝分裂原（Con-A、PHA）的最佳浓度保持不变，而B细胞促有丝分裂原（LPS）的最佳浓度则随着培养基中谷氨酰胺浓度的增加而增加。
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