City Dispensary for Skin and Venereal Diseases, School of Medicine, Belgrade University, 11000 Belgrade, Serbia.
Br J Dermatol. 2011 Feb;164(2):325-9. doi: 10.1111/j.1365-2133.2010.10091.x.
Lichen sclerosus (LS) is an inflammatory disease of the skin and mucous membranes. Its aetiology is still unknown.
To determine risk factors for genital LS in men.
In a case-control study, 73 patients with LS, consecutively diagnosed at the City Dispensary for Skin and Venereal Diseases in Belgrade, were compared with 219 male patients visiting the same institution because of tinea cruris. Univariate and multivariate logistic regression analyses were used for analysis of data collected.
According to multivariate logistic regression analysis, risk factors for male LS were as follows: a personal history of genital injury [odds ratio (OR) 28·1, 95% confidence interval (CI) 5·2-150·8], vitiligo (OR 23·1, 95% CI 2·2-240·2), alopecia areata (OR 8·8, 95% CI 1·1-68·5) and hypercholesterolaemia (OR 3·1, 95% CI 1·1-8·2), and a family history of alopecia areata (OR 24·3, 95% CI 2·1-280·7), diseases of the thyroid gland (OR 9·1, 95% CI 2·3-36·2) and other autoimmune diseases (OR 8·6, 95% CI 1·3-58·6).
The results of the present study are in line with the hypothesis that trauma of the penis is a possible trigger of symptoms in genetically predisposed individuals and that personal and family histories of autoimmune disorders are risk factors for male LS.
硬化性苔藓（LS）是一种皮肤和黏膜的炎症性疾病。其病因尚不清楚。
确定男性生殖器 LS 的危险因素。
在一项病例对照研究中，连续在贝尔格莱德市皮肤病和性病门诊部诊断为 LS 的 73 例患者与因股癣就诊于同一机构的 219 例男性患者进行了比较。采用单变量和多变量逻辑回归分析收集的数据进行分析。
根据多变量逻辑回归分析，男性 LS 的危险因素如下：生殖器损伤史[比值比 (OR) 28·1，95%置信区间 (CI) 5·2-150·8]、白癜风 (OR 23·1，95% CI 2·2-240·2)、斑秃 (OR 8·8，95% CI 1·1-68·5) 和高胆固醇血症 (OR 3·1，95% CI 1·1-8·2)，以及斑秃家族史 (OR 24·3，95% CI 2·1-280·7)、甲状腺疾病 (OR 9·1，95% CI 2·3-36·2) 和其他自身免疫性疾病 (OR 8·6，95% CI 1·3-58·6)。
本研究结果与以下假设一致，即阴茎创伤可能是遗传易感性个体症状的触发因素，个人和家族自身免疫性疾病史是男性 LS 的危险因素。
